The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, imipramine, carbamazepine, oxazepam, promethazine, and theophylline. Of the tested compounds, promethazine and imipramine were the most effectively adsorbed to diosmectite. Their adsorption to diosmectite (0.356±0.029mg promethazine/mg diosmectite and 0.354±0.019mg imipramine/mg diosmectite, respectively) was significantly higher than their adsorption to activated charcoal. The effect of temperature and pH on the adsorption efficiencies was also evaluated. In the case of experiments with mixture of both adsorbents, they mostly behaved in a solution independently or in a slightly antagonistic way. Using various methods such as N2 adsorption and thermogravimetric analysis, the structure and texture of diosmectite and activated charcoal were attained.
- MeSH
- adsorpce MeSH
- alfa-amanitin chemie MeSH
- amlodipin chemie MeSH
- antidota chemie MeSH
- Aspirin chemie MeSH
- digoxin chemie MeSH
- dřevěné a živočišné uhlí chemie MeSH
- fenobarbital chemie MeSH
- ibuprofen chemie MeSH
- imipramin chemie MeSH
- karbamazepin chemie MeSH
- otrava prevence a kontrola MeSH
- oxazepam chemie MeSH
- promethazin chemie MeSH
- silikáty chemie MeSH
- theofylin chemie MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
