Bilateral complete cleft lip and palate (BCLP) is the most severe of the common orofacial clefts and is associated with the greatest deformity during development. The aim of this study was to use geometric morphometrics to evaluate palatal shape and size variability in patients with BCLP in comparison to nonclefted Czech boys. The variability of palatal size and shape in BCLP patients was greater when compared with the nonclefted population. Though palate variability in BCLP was wide, nonclefted palatal shapes were generally different (a high, wide and vaulted palate) and fell almost outside the range of BCLP variability. The palatal size and shape of BCLP patients (range from 12.1 to 16.5 years) was not correlated with age. A comparison of the mean shapes of the clefted and nonclefted groups showed that the BCLP palate is flatter and narrower. The most notable size difference was found in the area between the maxilla and premaxilla. This phenomenon is associated with the persisting separation of the premaxilla from the rest of the palate. The shape of the palatal configuration of the premaxilla and adjacent area was concave in the nonclefted group and convex in BCLP patients.

• MeSH
• analýza hlavních komponent metody   MeSH
• analýza metodou konečných prvků MeSH
• anatomická značka patologie   MeSH
• chirurgické laloky MeSH
• dítě MeSH
• kefalometrie metody   MeSH
• lasery MeSH
• lidé MeSH
• maxila patologie   MeSH
• mladiství MeSH
• ortodoncie korekční metody   MeSH
• patro patologie   MeSH
• počítačové zpracování obrazu metody   MeSH
• rozštěp patra patologie   terapie   MeSH
• zákroky plastické chirurgie metody   MeSH
• zobrazování trojrozměrné metody   MeSH
• zubní modely MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH

The aim of this study was to introduce suitable imaging technique and analytical methods for a detailed description of the facial movements in relation to sexual dimorphism and age in adult individuals. Removing of size factor from the analysis, we hypothesised that there will be no significant intersexual difference in facial mobility. We assume facial movements to be more pronounced in the older age category due to increasing the facial surface. We have compared five facial movements - raising eyebrows, closing eyes, pursing of the lips, inflating of the cheeks and smile - in relation to neutral expression of the human face. The material sample comprised three-dimensional facial surface models of healthy adult individuals of the Czech nationality (63 females, 58 males). Methods of geometric morphometry and multivariate statistics were used. Local tissue motion due to facial movements was expressed using colour-coded maps. The movement showing significant intersexual difference was inflating of the cheeks. Ageing in both sexes has significantly influenced the facial mobility on average after 50 years of age. Changes related to senescence have occurred in eye closing, smile and inflating of the cheeks. An enlarged facial surface has been noted in the group of individuals belonging to the older age category, what is probably the result of increased manifestation of skin folds and wrinkles. This is related to the loss of skin elasticity and overall weakening of the underlying muscles, especially in the infraorbital and cheeks area.

• MeSH
• analýza rozptylu MeSH
• anatomické modely MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• obličej anatomie a histologie   MeSH
• pohlavní dimorfismus * MeSH
• pohyb MeSH
• stárnutí patologie   fyziologie   MeSH
• výraz obličeje * MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Facial development of patients with unilateral complete cleft lip and palate (UCLP) is associated with many problems including deformity of the palate. The aim of this study was to evaluate palatal morphology and variability in patients with UCLP compared with Czech norms using methods of geometric morphometrics. The study was based on virtual dental cast analysis of 29 UCLP patients and 29 control individuals at the age of 15 years. The variability of palatal shape in UCLP patients was greater than that in nonclefted palates. Only 24% of clefted palates fell within the variability of controls. The palatal form of UCLP patients (range from 11.8 to 17.2 years) was not correlated with age. Compared with control palates, palates of UCLP patients were narrower, more anteriorly than posteriorly. Apart from the praemaxilla region, they were also shallower, and the difference increased posteriorly. The UCLP palate was characterised by the asymmetry of its vault. The maximum height of the palatal vault was anterior on the clefted side, whereas it was posterior on the nonclefted side. The slope of the UCLP palate was more inclined compared with the control group. The praemaxilla was therefore situated more inferiorly.

• MeSH
• anatomická variace MeSH
• anatomická značka patologie   MeSH
• dítě MeSH
• kefalometrie metody   MeSH
• lidé MeSH
• maxila patologie   MeSH
• mladiství MeSH
• patro patologie   MeSH
• počítačové zpracování obrazu metody   MeSH
• rozštěp patra patologie   MeSH
• rozštěp rtu patologie   MeSH
• uživatelské rozhraní počítače MeSH
• věkové faktory MeSH
• zákroky plastické chirurgie metody   MeSH
• zobrazování trojrozměrné metody   MeSH
• zubní modely MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH

Developing method of objective evaluation of shape-changes of the dental arch and palate in a single patient by means of a superposition of 3D computer models. An application of advanced methods of geometric morphometrics to the study of the size and shape of the dental arch and palate. A three-dimensional analysis of the post-operative development of the dental arch and palate in patients with a submucous cleft palate and patients with maxillary transversal deficiency.

Vývoj metody objektivního hodnocení postoperačních změn velikosti a tvaru zubního oblouku a patra u konkrétního pacienta pomocí superpozice trojrozměrných počítačových modelů. Aplikace pokročilých metod geometrické morfometrie ve výzkumu tvaru a velikosti zubního oblouku a patra, umožňující kvantitativní analýzu vlivu jednotlivých typů chirurgických zákroků na růst a a vývoj zubního oblouku a patra u větších souborů pacientů. Trojrozměrná analýza postoperačního vývoje patra u pacientů se submukózním rozštěpem patra a pacientů s transverzální kompresí horního zubního oblouku.

• MeSH
• ortognátní chirurgie metody   MeSH
• rozštěp patra MeSH
• zobrazování trojrozměrné MeSH

• Konspekt
• Stomatologie
• NLK Obory
• zubní lékařství
• radiologie, nukleární medicína a zobrazovací metody
• NLK Publikační typ
• závěrečné zprávy o řešení grantu IGA MZ ČR

Sexual dimorphism is responsible for a substantial part of human facial variability, the study of which is essential for many scientific fields ranging from evolution to special biomedical topics. Our aim was to analyse the relationship between size variability and shape facial variability of sexual traits in the young adult Central European population and to construct average surface models of adult males and females. The method of geometric morphometrics allowed not only the identification of dimorphic traits, but also the evaluation of static allometry and the visualisation of sexual facial differences. Facial variability in the studied sample was characterised by a strong relationship between facial size and shape of sexual dimorphic traits. Large size of face was associated with facial elongation and vice versa. Regarding shape sexual dimorphic traits, a wide, vaulted and high forehead in combination with a narrow and gracile lower face were typical for females. Variability in shape dimorphic traits was smaller in females compared to males. For female classification, shape sexual dimorphic traits are more important, while for males the stronger association is with face size. Males generally had a closer inter-orbital distance and a deeper position of the eyes in relation to the facial plane, a larger and wider straight nose and nostrils, and more massive lower face. Using pseudo-colour maps to provide a detailed schematic representation of the geometrical differences between the sexes, we attempted to clarify the reasons underlying the development of such differences.

• MeSH
• analýza metodou konečných prvků MeSH
• anatomické modely MeSH
• čelo anatomie a histologie   MeSH
• faciální stigmatizace MeSH
• lidé MeSH
• mladý dospělý MeSH
• nos anatomie a histologie   MeSH
• oči anatomie a histologie   MeSH
• pohlavní dimorfismus MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Geografické názvy
• Evropa MeSH

OBJECTIVE: To assess modelled facial development of infants with unilateral cleft lip (CL) and cleft lip and palate (UCLP) compared to controls up to two years of age. DESIGN AND PARTICIPANTS: A total of 209 facial images of children (CL: n = 37; UCLP: n = 39; controls: n = 137) were obtained in four age categories (T0 = 0.2-0.5; T1 = 0.6-1.0; T2 = 1.1-1.5; T3 = 1.6-2.0 years) and were evaluated using stereophotogrammetry and geometric morphometry. All patients underwent lip surgery before T0, patients with UCLP underwent palatoplasty (T0, T1 before palatoplasty; T2, T3 after palatoplasty). RESULTS: In patients with CL, the forehead was significantly retracted (p ≤ 0.001), while the supraorbital and ocular regions were prominent (p ≤ 0.001). The oronasal region appeared convex (p ≤ 0.001). The lower lip and chin were non-significantly protruded. In patients with UCLP, a significantly retracted forehead and prominent supraorbital region were apparent (p ≤ 0.001). A retrusive oronasal region (p ≤ 0.001) was observed in the middle face. The chin was anteriorly protruded (p ≤ 0.01). No progression of deviations was found with increasing age. After the first year, a slight improvement in the morphological features became apparent. The shape variability of the clefts and controls overlapped, suggesting a comparable modelled facial development. CONCLUSIONS: The facial morphology of individuals with cleft was comparable to the norm. Shape deviation was apparent in the oronasal region, forehead, and chin, which minimised with increasing age even in complete clefts.

• MeSH
• fotogrammetrie * metody   MeSH
• kefalometrie MeSH
• kojenec MeSH
• lidé MeSH
• maxilofaciální vývoj MeSH
• obličej anatomie a histologie   abnormality   MeSH
• předškolní dítě MeSH
• průřezové studie MeSH
• rozštěp patra * chirurgie   diagnostické zobrazování   patologie   MeSH
• rozštěp rtu * chirurgie   patologie   MeSH
• studie případů a kontrol MeSH
• zobrazování trojrozměrné * MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

OBJECTIVES: Since the normal, non-pathological facial growth in preschool children is not sufficiently reported, the aim was to follow growth changes of facial surface, sex differences and facial variability in preschool children using 3D stereophotogrammetry. SETTINGS AND SAMPLE POPULATION: Mixed longitudinal sample of healthy Caucasian preschool children without head and facial trauma or craniofacial anomalies from 3.4 to 6.7 years of age consisted of 25 girls and 17 boys. MATERIALS AND METHODS: 136 3D facial models from optical scanner Vectra 3D were evaluated by geometric morphometrics (CPC-DCA, PCA, per-vertex t test). RESULTS: In both sexes, the lower face was widened and elongated, and the prominences of the superciliary arches, lower orbital region, nose, lips and chin increased. Facial surface increments were more even in girls with a maximum between the fourth and fifth year of age, while in boys, there was the most intensive growth between fifth and sixth year of age. Sexual dimorphism was very stable during investigated period, only less statistically significant at the age of 3 years. Boys had more prominent lateral lower part of forehead, nose and lips than girls in every age category. CONCLUSIONS: The longitudinal growth of the face between third and sixth year of age was similar in both sexes, facial sex differences were found in terms of intensity, size and timing. Variability of facial form showed that boys' faces were larger on average and facial shape did not differ. The knowledge of facial growth is essential for diagnostics and clinical practice.

• MeSH
• fotogrammetrie * MeSH
• kefalometrie MeSH
• lidé MeSH
• longitudinální studie MeSH
• nos anatomie a histologie   diagnostické zobrazování   MeSH
• obličej anatomie a histologie   diagnostické zobrazování   MeSH
• předškolní dítě MeSH
• zobrazování trojrozměrné * MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Determination of sex is one of the most important and challenging disciplines in biological anthropology. Creating a robust tool for sexing crania is crucial for forensic anthropology, especially in this period of migration, travel, and globalization, when different populations are mixed together in one region. Many different approaches to sex estimation using the skull have been published; however, population specificity and oscillation of variable sexual dimorphism typically reduces their effectiveness. The aim of this study was to create a robust classifier using virtual anthropology without the use of a CT scanner. The entire cranial surface was analyzed using coherent point drift-dense correspondence analysis and classification was performed using a support vector machine with a radial kernel, minimizing subjective error. The study sample consisted of 103 CT scans of a recent southern French population. Virtual scans of 52 males and 51 females (age from 18 to 92) were analyzed using 3D software systems (Rapidform, Avizo, Morphome3cs) and innovative approaches in geometric morphometrics. Leave-one-out crossvalidation was also applied. Sex differences in shape and form were displayed by colour scale maps. The whole cranial surface was significantly different between males and females in size (form). Sexual dimorphism was significantly lower in senile skulls. The most exclusive areas were the supraorbital region, orbits, cheek bones, nasal apertures, mastoids, and external occipital protuberances. The method provided a high level of classification accuracy (90.3%) in sexing male and female skulls and is a valuable tool for sex determination.

• MeSH
• dospělí MeSH
• lebka anatomie a histologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• soudní antropologie MeSH
• support vector machine MeSH
• určení pohlaví podle kostry metody   MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Francie MeSH

One of the most fundamental issues in forensic anthropology is the determination of sex and population affinity based on various skeletal elements. Therefore, we compared the sexual dimorphism of the upper facial skeleton from a recent Czech population (twenty-first century) with that of a population from Early Modern Age Bohemia (sixteenth to eighteenth centuries). Methods of geometric morphometrics were applied. According to the results, sexual dimorphism in terms of size, shape, and form was statistically significant in both populations. The best results of sex estimation originated from analyses of form. Thus, both size and shape differences should be taken into account for determination of the sex. The accuracy of prediction achieved 91.1% for individuals in the recent population and 87.5% for individuals from the early modern population. Only minor differences were found between sexual dimorphism in the studied populations. We conclude that sexual dimorphism of the upper facial skeleton is stable during the relatively short time period.

• MeSH
• analýza hlavních komponent MeSH
• anatomická značka MeSH
• dospělí MeSH
• lebka anatomie a histologie   diagnostické zobrazování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• obličejové kosti anatomie a histologie   diagnostické zobrazování   MeSH
• počítačová rentgenová tomografie MeSH
• soudní antropologie MeSH
• support vector machine MeSH
• určení pohlaví podle kostry * MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

OBJECTIVES: Facial directional asymmetry research, including age-related changes, is crucial for the evaluation of treatment of craniofacial malformations/trauma in orthodontics, facial surgery and forensic sciences. The aim was to describe facial directional asymmetry (DA) in different age categories of adults using 3D methods. According to our hypothesis, facial shape DA (1) depends on sex; (2) differs among age groups; and (3) has wider variability in older age. MATERIAL AND METHODS: A cross-sectional sample of healthy Czech adults without craniofacial trauma or anomalies consisted of 300 3D facial models (151 females). The age-range in the study was between 20-80 years. The shape asymmetry of 28 3D landmarks was evaluated using geometric morphometrics and multivariate statistics. RESULTS: The manifestation of DA was similar in both sexes and in each age category; however, there were some statistical differences. In contrast to the ideal symmetrical face, the mean asymmetrical faces tended to create a slightly bent "C" shape of the midline. Therefore, the upper face was rotated slightly clockwise and the lower face counter-clockwise. The right eye was located slightly higher, with the nasal tip and mandibular region tilting to the left. Sex differences in facial DA were significant before the age of 40. DA was more significant in the youngest males than in the oldest, while the women's DA did not change. CONCLUSIONS: The DA patterns were similar in both sexes and in all age categories (a slightly bent C shape of the midline); however, some significant local differences between male age groups were found. A significantly more pronounced asymmetry compared to other age groups was found only in the youngest males from 20 to 40 years. Moreover, significant sexual dimorphism of DA rapidly decreased after middle age, likely caused by the same age-related changes of the face during aging.

• MeSH
• asymetrie obličeje * etiologie   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• nos MeSH
• pohlavní dimorfismus MeSH
• průřezové studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• zobrazování trojrozměrné * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH