COLFORSIN
      
        
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- MeSH
- adrenalin farmakologie MeSH
- kolforsin farmakologie MeSH
- krabi MeSH
- myofibrily MeSH
- vápníkové kanály MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
The adenylyl cyclase (AC) signaling pathway is suggested to be a key regulator of immune system functions. However, specific effects of cyclic adenosine monophosphate (cAMP) on T helper (Th) cell differentiation and functions are unclear. The involvement of cAMP in the Th cell differentiation program, in particular the development of Th1, Th2, and Th17 subsets, was evaluated employing forskolin (FSK), a labdane diterpene well known as an AC activator. FSK mediated an elevation in Th1-specific markers reinforcing the Th1 cell phenotype. The Th2 differentiation was supported by FSK, though cell metabolism was negatively affected. In contrast, the Th17 immunophenotype was severely suppressed leading to the highly specific upregulation of CXCL13. The causality between FSK-elicited cAMP production and the observed reinforcement of Th2 differentiation was established by using AC inhibitor 2',5'-dideoxyadenosine, which reverted the FSK effects. Overall, an FSK-mediated cAMP increase affects Th1, Th2 and Th17 differentiation and can contribute to the identification of novel therapeutic targets for the treatment of Th cell-related pathological processes.
- MeSH
- aktivace lymfocytů * MeSH
- AMP cyklický * MeSH
- buněčná diferenciace MeSH
- buňky Th17 MeSH
- kolforsin farmakologie MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- cystická fibróza * MeSH
- individualizovaná medicína MeSH
- kolforsin farmakologie MeSH
- lidé MeSH
- mutace MeSH
- protein CFTR genetika MeSH
- střevní sliznice MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- dopisy MeSH
- MeSH
- adenylátcyklasy analýza fyziologie účinky léků MeSH
- amfetamin farmakologie MeSH
- fyziologický stres MeSH
- imobilizace MeSH
- kolforsin farmakologie MeSH
- krysa rodu rattus MeSH
- zadní lalok hypofýzy enzymologie účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH
