• MeSH
• Headache drug therapy   MeSH
• Migraine Disorders drug therapy   MeSH
• Disease Models, Animal MeSH
• Drug Monitoring MeSH
• Publication type
• Congress MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• farmacie a farmakologie
• neurologie

BACKGROUND: According to the International Classification of Headache Disorders 3, post-traumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary headache reported to have developed within 7 days from head injury, regaining consciousness following the head injury, or discontinuation of medication(s) impairing the ability to sense or report headache following the head injury. It is one of the most common secondary headache disorders, and it is defined as persistent when it lasts more than 3 months. MAIN BODY: Currently, due to the high prevalence of this disorder, several preclinical studies have been conducted using different animal models of mild TBI to reproduce conditions that engender PTH. Despite representing a simplification of a complex disorder and displaying different limitations concerning the human condition, animal models are still a mainstay to study in vivo the mechanisms of PTH and have provided valuable insight into the pathophysiology and possible treatment strategies. Different models reproduce different types of trauma and have been ideated in order to ensure maximal proximity to the human condition and optimal experimental reproducibility. CONCLUSION: At present, despite its high prevalence, PTH is not entirely understood, and the differential contribution of pathophysiological mechanisms, also observed in other conditions like migraine, has to be clarified. Although facing limitations, animal models are needed to improve understanding of PTH. The knowledge of currently available models is necessary to all researchers who want to investigate PTH and contribute to unravel its mechanisms.

• MeSH
• Brain Concussion complications   diagnosis   physiopathology   MeSH
• Humans MeSH
• Migraine Disorders diagnosis   etiology   physiopathology   MeSH
• Disease Models, Animal * MeSH
• Post-Traumatic Headache diagnosis   etiology   physiopathology   MeSH
• Prevalence MeSH
• Reproducibility of Results MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

• MeSH
• Headache MeSH
• Migraine Disorders MeSH
• Brain Diseases MeSH
• Neurology MeSH
• Inflammation MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• neurologie
• neurovědy

• MeSH
• Stimulation, Chemical MeSH
• Electric Stimulation MeSH
• Financing, Organized MeSH
• Humans MeSH
• Migraine with Aura MeSH
• Migraine Disorders genetics   physiopathology   MeSH
• Disease Models, Animal MeSH
• Models, Animal MeSH
• Models, Molecular MeSH
• Cortical Spreading Depression physiology   MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Review MeSH

Cíl studie: Cílem studie bylo podpořit předpoklad asociace migrény a deprese metaanalytickou studií. Metodika: Zkoumali jsme 20 populačních průřezových studií testujících asociaci migrény s depresí. Pro metaanalýzu jsme použili poměr šancí (OR) a modely náhodných efektů. K identifikaci zdrojů heterogenity jsme studie rozdělili na základě metod použitých pro dia­gnózu migrény a deprese, způsobu výběru a kontaktu osob, lokality. Vliv procentuálního zastoupení žen ve studiích a velikosti souboru jsme ověřovali metaregresí. Publikační zkreslení jsme pak zkoumali inspekcí trychtýřového grafu a testovali Eggerovým regresním testem. Výsledky: U osob s migrénou lze očekávat třikrát vyšší výskyt depresivní symptomatologie (OR = 3,11; 95% CI 2,43–3,98) ve srovnání s jedinci bez migrény. Testy vlivu potenciálních moderujících proměnných byly, s výjimkou diference mezi OR studiemi s přímým a nepřímým kontaktem (Qdif = 6,32; p = 0,012), statisticky nevýznamné. Variabilita OR byla, na rozdíl od vlivu procentuálního zastoupení žen ve studiích, statisticky významně ovlivněna velikostí souborů (Qmodel = 5,07; df = 1; p = 0,027). Publikační zkreslení nebylo zjištěno (tdf = 18 = 1,72; p = 0,10). Závěr: Výsledky naznačují výraznou komorbiditu migrény a deprese. Vzhledem k tomu, že deprese je považována za rizikový faktor chronicity migrény, mělo by být monitorování depresivní symptomatologie u migreniků nedílnou součástí terapie.

The aim of the study: The aim of our study was to support the supposition of an association between migraine and depression. Methods: We reviewed 20 population-based cross-sectional studies focused on migraine in association with depression. For meta-analysis, we used odds ratio (OR) and random effects models. In the search for sources of heterogeneity, we subdivided the studies on the basis of method of migraine and depression diagnosis, sampling, type of contact with subjects, and locality. The effect of proportional representation of females and sample size on OR variability was tested with meta-regression. Publication bias was verified by a funnel plot and by the Egger’s regression test. Results: Three times higher incidence of depressive symptomology is expected in migraineurs compared with non-migraineurs (OR = 3.11; 95% CI 2.43–3.98). The effect of potential moderators was, apart from the difference in OR between studies with direct and indirect contact (Qdif = 6.32; p = 0.012), statistically insignificant. The OR variance was statistically significantly influenced by study size (Qmodel = 5.07; df = 1; p = 0.027). There was no evidence for publication bias as tested by the visual inspection of the funnel plot and by Egger’s regression intercept (t = 1.92; df = 18; p = 0.10). Conclusion: The findings indicate strong comorbidity of migraine and depression. As depression is believed to be a risk factor for migraine chronification, monitoring of depressive symptomatology should be integral part of therapy. Key words: migraine – depression – meta-analysis The authors declare they has no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.

• MeSH
• Depression * epidemiology   MeSH
• Adult MeSH
• Comorbidity * MeSH
• Middle Aged MeSH
• Humans MeSH
• Migraine Disorders * epidemiology   MeSH
• Adolescent MeSH
• Young Adult MeSH
• Odds Ratio MeSH
• Regression Analysis MeSH
• Chi-Square Distribution MeSH
• Aged MeSH
• Statistics as Topic MeSH
• Bias MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Meta-Analysis MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Biomedical Research MeSH
• Child MeSH
• Adult MeSH
• Physiology MeSH
• Clinical Medicine MeSH
• Pathology MeSH
• Check Tag
• Child MeSH
• Adult MeSH

• Conspectus
• Experimentální medicína
• Učební osnovy. Vyučovací předměty. Učebnice
• NML Fields
• patologie
• fyziologie
• NML Publication type
• učebnice vysokých škol
• kolektivní monografie

• MeSH
• Analgesia methods   trends   utilization   MeSH
• Pain diagnosis   drug therapy   MeSH
• Treatment Outcome MeSH
• Publication type
• Congress MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• anesteziologie a intenzivní lékařství

• MeSH
• Pharmacy MeSH
• Herbal Medicine MeSH
• Plants, Medicinal MeSH
• Medicine, Traditional MeSH
• Publication type
• Pharmacopoeia MeSH

• Conspectus
• Farmacie. Farmakologie
• NML Fields
• farmacie a farmakologie
• NML Publication type
• publikace WHO