Fast field cycling (FFC) NMR relaxometry has been used to study the conformational properties of aqueous solutions of hyaluronan (HYA) at three concentrations in the range 10 to 25 mg mL(-1). Results revealed that, irrespective of the solution concentration, three different hydration layers surround hyaluronan. The inner layer consists of water molecules strongly retained in the proximity of the HYA surface. Because of their strong interactions with HYA, water molecules in this inner hydration layer are subject to very slow dynamics and have the largest correlation times. The other two hydration layers are made of water molecules which are located progressively further from the HYA surface. As a result, decreasing correlation times caused by faster molecular motion were measured. The NMRD profiles obtained by FFC-NMR relaxometry also showed peaks attributable to (1)H-(14)N quadrupole interactions. Changes in intensity and position of the quadrupolar peaks in the NMRD profiles suggested that with increasing concentration the amido group is progressively involved in the formation of weak and transient intramolecular water bridging adjacent hyaluronan chains. In this work, FFC-NMR was used for the first time to obtain deeper insight into HYA-water interactions and proved itself a powerful and promising tool in hyaluronan chemistry.

• MeSH
• Carbohydrate Conformation MeSH
• Hyaluronic Acid chemistry   MeSH
• Magnetic Resonance Spectroscopy methods   MeSH
• Water chemistry   MeSH
• Publication type
• Journal Article MeSH
• Evaluation Study MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Food, Organic MeSH

• Conspectus
• Kuchařství. Potraviny. Vařená jídla
• NML Fields
• zemědělství a potravinářství
• NML Publication type
• brožury

• Publication type
• Meeting Abstract MeSH

Učebnice, jež není totožná se starší stejnojmennou příručkou, se zaměřuje především na výcvik řečových dovedností. Ve třiceti lekcích s dialogickými texty - obsahujícími jednak frazeologické vazby a jednak mluvnické příklady -podává základy hovorové angličtiny, mluvnice a výslovnosti

• MeSH
• Textbooks as Topic MeSH

• Keywords
• učebnice jazykové, angličtina, samouci,
• Publication type
• Textbook MeSH

• NML Fields
• lingvistika, lékařská terminologie

Setting of maximum limits for a number of plant alkaloids is under discussion in the EU. The novel method developed and optimized in this study enables simultaneous determination of 21 tropane alkaloids (TAs) and 33 pyrrolizidine (PAs) together with their N-oxides (PANOs). For analysis of aqueous-methanolic extract, reversed phase ultra-high-performance liquid chromatography and tandem mass spectrometry (RP-U-HPLC-MS/MS) was employed. The method was validated for frequently contaminated matrices (i) sorghum, (ii) oregano, and (iii) mixed herbal tea. The recoveries at two spiking levels were in the range of 82-115%, 80-106%, and 78-117%, respectively, and repeatabilities were less than 19% for all analyte/matrix combinations. As regards the achieved limits of quantification (LOQ), their values were in the range of 0.5-10 μg kg-1. The crucial problem encountered during method development, co-elution of multiple groups of isomeric alkaloids, was overcome by subsequent sample separation in the second chromatographic system, hydrophilic interaction liquid chromatography (HILIC), providing different separation selectivity. Lycopsamine, echinatine, and indicine (co-elution group 1) and N-oxides of indicine and intermedine (co-elution group 2), which could not be resolved on the commonly used RP column, were possible to separate fully by using the HILIC system.

• MeSH
• Alkaloids analysis   MeSH
• Isomerism MeSH
• Food Contamination analysis   MeSH
• Limit of Detection MeSH
• Pyrrolizidine Alkaloids analysis   MeSH
• Reproducibility of Results MeSH
• Plants chemistry   MeSH
• Tandem Mass Spectrometry methods   MeSH
• Tropanes analysis   MeSH
• Chromatography, High Pressure Liquid methods   MeSH
• Publication type
• Journal Article MeSH

Příručka se zaměřuje na metody komunikace s dítětem, která má poruchu řeči, ve školce. Určeno odborné veřejnosti, zejména učitelům.; Kniha si klade za cíl ukázat, že i malé úpravy a drobná opatření za využití stávajících prostředky a materiálů, které má mateřská škola a rodina k dispozici, mohou vést k rozvoji komunikace a lepšímu dorozumění a interakci s neverbálním dítětem.A to nejen mezi učitelem a dítětem, ale i dětmi navzájem. Autorky nenabízejí složité metody nebo přesně strukturované postupy, ale spíše způsob, jak o podpoře komunikace v dětské skupině přemýšlet a jak pracovat možná trochu poučeněji s tím, co se již v prostředí mateřské školy běžně užívá. Nakladetelská anotace. Kráceno.

• MeSH
• Child Language MeSH
• Communication MeSH
• Speech Disorders therapy   MeSH
• Children with Disabilities education   MeSH
• Child, Preschool education   MeSH
• Schools, Nursery MeSH
• Education, Special MeSH
• Check Tag
• Child, Preschool education   MeSH
• Publication type
• Handbook MeSH

• Conspectus
• Výchova a vzdělávání zvláštních skupin osob
• NML Fields
• logopedie, klinická logopedie
• pedagogika
• pediatrie

• MeSH
• Allergens MeSH
• Hypersensitivity MeSH
• Antigens, Plant MeSH
• Pollen immunology   MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Obecná botanika
• NML Fields
• botanika
• alergologie a imunologie
• NML Publication type
• studie

Rozbor zdravotně sociálních služeb pro seniory. Autor knihy se snaží nastínit směr, jakým by se měly ubírat místní a krajské samosprávy v této problematice.

• MeSH
• Community Medicine MeSH
• Community Health Nursing MeSH
• Delivery of Health Care MeSH
• Social Work MeSH
• Community Networks MeSH
• Community Health Services MeSH
• Geographicals
• Czech Republic MeSH

• Conspectus
• Druhy sociální pomoci a služeb
• NML Fields
• sociální lékařství
• NML Publication type
• informační publikace

• MeSH
• Physicians MeSH
• Medicine MeSH
• Science MeSH
• Famous Persons MeSH
• Health Personnel MeSH
• Publication type
• Interview MeSH
• Geographicals
• Czech Republic MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• lékařství
• NML Publication type
• brožury