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Background: Pelvic, spinal and hips asymmetries constitute common phenomena. Pelvic asymmetry is usually perceived from two different points of view: as a causative factor in certain motor system dysfunctions or as a symptom of existing dysfunctions. Objective: This study aimed to evaluate the difference in activation asymmetry of lateral abdominal muscles (LAM) and the difference in body weight distribution on lower extremities during prolonged standing between subjects with and without pelvic asymmetry, and check if there is a correlation between the magnitude of pelvic asymmetry and activation asymmetry of lateral abdominal muscles as well as body weight distribution on lower extremities. Methods: A total of 66 subjects (34 women) participated in the study. LAM activation was measured using ultrasound technology. Body weight distribution asymmetry on lower extremities was measured during prolonged barefoot standing on the two scales equipped with digital readings. The activation asymmetry index and the weight distribution asymmetry index between the left and right sides of the body were calculated. Results: The recorded weight distribution asymmetry indexes were slightly higher in subjects with pelvic asymmetry; however, no significant inter-group differences were found. These subjects did not show any significant difference from subjects without asymmetry for activation asymmetry index recorded in all individual LAMs (obliquus externus abdominis p = .68, obliquus internus abdominis p = .34, transversus abdominis p = .55). Conclusions: No differences were found between subjects with and without pelvic asymmetry in activation asymmetry of lateral abdominal muscles and body weight distribution on lower extremities. Thus, there was no evidence gathered to prove that pelvic asymmetry constitutes an advantageous or disadvantageous phenomenon. It seems that it may play only a minor role, if any, in the energy expenditure optimisation process during prolonged standing. It is unlikely that pelvic asymmetry may lead to or stem from activation asymmetry of lateral abdominal muscles.
- Klíčová slova
- asymetrie,
- MeSH
- břišní svaly diagnostické zobrazování MeSH
- dospělí MeSH
- lidé MeSH
- muskuloskeletální systém MeSH
- pánev * abnormality diagnostické zobrazování MeSH
- stoj * MeSH
- tělesná hmotnost MeSH
- ultrasonografie metody MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- klinická studie MeSH
The 5-year mortality rate for heart failure borders on 50%. The main cause is an ischaemic cardiac event where blood supply to the tissue is lost and cell death occurs. Over time, this damage spreads and the heart is no longer able to pump efficiently. Increasing vascularisation of the affected area has been shown to reduce patient symptoms. The growth factors required to do this have short half-lives making development of an efficacious therapy difficult. Herein, the angiogenic growth factor Vascular Endothelial Growth Factor (VEGF) is complexed electrostatically with star-shaped or linear polyglutamic acid (PGA) polypeptides. Optimised PGA-VEGF nanomedicines provide VEGF encapsulation of > 99% and facilitate sustained release of VEGF for up to 28 days in vitro. The star-PGA-VEGF nanomedicines are loaded into a percutaneous delivery compliant hyaluronic acid hydrogel. Sustained release of VEGF from the composite nano-in-gel system is evident for up to 35 days and the released VEGF has comparable bioactivity to free, fresh VEGF when tested on both Matrigel® and scratch assays. The final star-PGA-VEGF nanomedicine-loaded hydrogel is biocompatible and provides sustained release of bioactive VEGF. Therefore, we report the development of novel, self-assembling PGA-VEGF nanomedicines and their incorporation into a hyaluronic acid hydrogel that is compatible with medical devices to enable minimally invasive delivery to the heart. The final star-PGA-VEGF nanomedicine-loaded hydrogel is biocompatible and provides sustained release of bioactive VEGF. This formulation provides the basis for optimal spatiotemporal delivery of an angiogenic growth factor to the ischaemic myocardium.
- MeSH
- aplikace kožní MeSH
- endoteliální buňky pupečníkové žíly (lidské) MeSH
- hydrogely MeSH
- ischemická choroba srdeční farmakoterapie MeSH
- kyselina polyglutamová chemie MeSH
- léky s prodlouženým účinkem MeSH
- lidé MeSH
- nanočástice MeSH
- statická elektřina MeSH
- vaskulární endoteliální růstový faktor A chemie farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. METHODS: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. RESULTS: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebello-thalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results - higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. CONCLUSION: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.
Pressurised fluid extraction using water or methanol was employed for the extraction of stevioside from Stevia rebaudiana Bertoni. The extraction method was optimised in terms of temperature and duration of the static or the dynamic step. Extracts were analysed by liquid chromatography followed by UV and mass-spectrometric (MS) detections. Thermal degradation of stevioside was the same in both solvents within the range 70-160 degrees C. Methanol showed better extraction ability for isolation of stevioside from Stevia rebaudiana leaves than water within the range 110-160 degrees C. However, water represents the green alternative to methanol. The limit of detection of stevioside in the extract analysed was 30 ng for UV detection and 2 ng for MS detection.
... -- IND -- Đ’ -- Patient satisfaction - A determinant of quality management 88 in hospitals -- Optimisation ... ... RÉSULTATS ET PERSPECTIVES -- Fostering consensus about financing institutional care for the aged -- OPTIMISATION ... ... Chlamydia trachomatis: Population based dynamic modeling leads to substantially different results than static ...
2 svazky (480, 384 stran) : ilustrace, tabulky ; 24 cm
- MeSH
- poskytování zdravotní péče organizace a řízení MeSH
- řízení zdravotnictví MeSH
- Publikační typ
- kongresy MeSH
- sborníky MeSH
