BACKGROUND: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with a duration of follow-up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (hazard ratio, 1.15; 95% CI, 1.14-1.16) per 5-year increase, male sex (hazard ratio, 1.17; 95% CI, 1.13-1.21) and smoking (hazard ratio, 1.43; 95% CI, 1.35-1.51) with risk of subsequent CHD death or myocardial infarction and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and nongenetic determinants of subsequent event risk in individuals with established CHD, to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
- MeSH
- dospělí MeSH
- koronární nemoc patologie MeSH
- kouření MeSH
- lidé středního věku MeSH
- lidé MeSH
- prognóza MeSH
- proporcionální rizikové modely MeSH
- rizikové faktory MeSH
- senioři MeSH
- sexuální faktory MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
PURPOSE: This study was designed to investigate the distribution of vasa vasorum in walls of failed aorto-coronary venous grafts. METHODS: Fifty-one diseased venous grafts harvested from 39 patients underwent qualitative histological evaluation. The morphology of the grade of the pathological changes and the extent of the vascularisation were examined, and related to the length of the interval between the primary surgery and the explantation. The obtained results were placed into five groups, substantially differing one from the other in morphology and vascularisation. RESULTS: The intervals between grafts implantation and explantation ranged from 1 day to 35 years. The onset of arterialization of the graft media was observed on average at 1 month after bypass implantation. During this same time period massive intimal hyperplasia and atherosclerosis occurred. Vasa vasorum proliferation from the adventitia to the outer layers of the media was first apparent between 7 and 24 months after implantation. Proliferation of the vasa vasorum throughout the entire atherosclerotic media and hyperplastic intima continued for a much longer time interval. CONCLUSION: No correlation between neoangiogenesis and age, sex or type of bypassed coronary branch was proven. Regarding the given findings, the authors believe that changes in hemodynamic conditions and endothelial trauma are primarily responsible for the development of graft disease and that vasa vasorum proliferation is only a secondary reaction to the structural changes of the graft wall. To what extent the frequently present pre-existing intimal hyperplasia of venous bypass grafts play in the development of graft disease remains questionable.
- MeSH
- aorta patologie chirurgie MeSH
- časové faktory MeSH
- koronární bypass metody MeSH
- koronární nemoc patologie chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- terapie neúspěšná MeSH
- vasa vasorum patologie MeSH
- vény patologie transplantace MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- dyslipidemie epidemiologie chemicky indukované MeSH
- hypertenze epidemiologie chemicky indukované MeSH
- imunosupresiva škodlivé účinky terapeutické užití MeSH
- koronární nemoc diagnóza patofyziologie patologie MeSH
- lékové interakce MeSH
- lidé MeSH
- nádory epidemiologie chemicky indukované prevence a kontrola MeSH
- následná péče metody organizace a řízení MeSH
- rejekce štěpu etiologie imunologie patofyziologie MeSH
- renální insuficience epidemiologie chemicky indukované MeSH
- transplantace srdce * kontraindikace ošetřování škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
Over the last two decades, the amount of evidence corroborating an association between dental plaque bacteria and coronary diseases that develop as a result of atherosclerosis has increased. These findings have brought a new aspect to the etiology of the disease. There are several mechanisms by which dental plaque bacteria may initiate or worsen atherosclerotic processes: activation of innate immunity, bacteremia related to dental treatment, and direct involvement of mediators activated by dental plaque and involvement of cytokines and heat shock proteins from dental plaque bacteria. There are common predisposing factors which influence both periodontitis and atherosclerosis. Both diseases can be initiated in early childhood, although the first symptoms may not appear until adulthood. The formation of lipid stripes has been reported in 10-year-old children and the increased prevalence of obesity in children and adolescents is a risk factor contributing to lipid stripes development. Endothelium damage caused by the formation of lipid stripes in early childhood may lead to bacteria penetrating into blood circulation after oral cavity procedures for children as well as for patients with aggressive and chronic periodontitis.
- MeSH
- ateroskleróza komplikace imunologie mikrobiologie patologie MeSH
- chronická parodontitida komplikace imunologie mikrobiologie patologie MeSH
- cytokiny genetika imunologie MeSH
- dítě MeSH
- dospělí MeSH
- exprese genu MeSH
- koronární nemoc komplikace imunologie mikrobiologie patologie MeSH
- lidé MeSH
- přirozená imunita MeSH
- proteiny tepelného šoku genetika imunologie MeSH
- rizikové faktory MeSH
- zubní plak komplikace imunologie mikrobiologie patologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Popisujeme kasuistiku pacienta s atypickými obtížemi indikovaného k operačnímu řešení na základě nálezu intravaskulárního ultrazvuku.
We report the case of a patient with atypical chest pain referred for surgery based on the finding of intravascular ultrasound.
- MeSH
- diagnostické techniky kardiovaskulární MeSH
- dospělí MeSH
- echokardiografie využití MeSH
- koronární angiografie metody trendy využití MeSH
- koronární bypass metody využití MeSH
- koronární nemoc komplikace patologie ultrasonografie MeSH
- lidé MeSH
- revaskularizace myokardu metody využití MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- balónková koronární angioplastika metody využití MeSH
- diabetes mellitus MeSH
- epidemiologické studie MeSH
- infarkt myokardu farmakoterapie patologie MeSH
- komorbidita MeSH
- koronární bypass metody využití MeSH
- koronární nemoc epidemiologie farmakoterapie patologie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- MeSH
- diagnostické techniky kardiovaskulární přístrojové vybavení trendy využití MeSH
- finanční podpora výzkumu jako téma MeSH
- kardiomyopatie diagnóza MeSH
- koronární nemoc diagnóza patologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody trendy využití MeSH
- myokard patologie MeSH
- myokarditida diagnóza MeSH
- nádory srdce diagnóza MeSH
- Check Tag
- lidé MeSH
- MeSH
- arterie chemie patologie MeSH
- arterioskleróza patologie MeSH
- endotelin-1 chemie MeSH
- imunohistochemie MeSH
- koronární nemoc patologie MeSH
- lidé MeSH
- receptory endotelinů chemie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
- MeSH
- arterioskleróza krev metabolismus MeSH
- cévní mozková příhoda metabolismus patologie prevence a kontrola MeSH
- hypercholesterolemie farmakoterapie komplikace prevence a kontrola MeSH
- hypertenze farmakoterapie komplikace prevence a kontrola MeSH
- hypolipidemika farmakologie metabolismus terapeutické užití MeSH
- koronární nemoc metabolismus patologie prevence a kontrola MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
