Pharmaceutical cocrystals are H-bonded multicomponent mixtures formed from a molecular or ionic substance and a cocrystal former, which are solids under ambient conditions. The cocrystals are the latest material investigated to enhance drug properties such as solubility, dissolution rate, stability, powder flow, and hygroscopicity. Very close to cocrystals are salts which can be distinguished by the localization of proton between an acid and base. Crystal engineering of cocrystals is based on the concept of supramolecular synthons. The major experimental techniques in cocrystal screening are cocrystallization in solution, solvent evaporation, melt crystallisation, dry cogrinding, solvent-assisted grinding and cryogrinding.
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- butyráty farmakologie chemie MeSH
- chemické jevy MeSH
- chemie farmaceutická metody trendy MeSH
- farmaceutická technologie metody trendy MeSH
- farmaceutický průmysl metody trendy MeSH
- financování organizované MeSH
- itrakonazol MeSH
- karbamazepin chemie MeSH
- kofein farmakologie chemie MeSH
- krystalizace metody trendy využití MeSH
- kyseliny dikarboxylové farmakologie chemická syntéza chemie MeSH
- kyseliny mandlové farmakologie chemie MeSH
- lékové formy MeSH
- objevování léků MeSH
- paracetamol farmakologie chemie MeSH
- rozpouštědla farmakologie chemie MeSH
- sacharin farmakologie chemie MeSH
- soli farmakologie chemie MeSH
An approach to stereoselective synthesis of alpha- or beta-3-C-glycosylated L- or D-1,2-glucals starting from the corresponding alpha- or beta-glycopyranosylethanals is described. The key step of the approach is the stereoselective cycloaddition of chiral vinyl ethers derived from both enantiomers of mandelic acid. The preparation of 1,5-anhydro-4,6-di-O-benzyl-2,3-dideoxy-3-C-[(2,3,4,6-tetra-O-benzyl-beta-D-glucopyranosyl)methyl]-L-arabino-hex-1-enitol, 1,5-anhydro-4,6-di-O-benzyl-2,3-dideoxy-3-C-[(2,3,4,6-tetra-O-benzyl-beta-D-glucopyranosyl)methyl]-D-arabino-hex-1-enitol, and 1,5-anhydro-4,6-di-O-benzyl-2,3-dideoxy-3-C-[(2,3,4-tri-O-benzyl-alpha-L-fucopyranosyl)methyl]-D-arabino-hex-1-enitol serves as an example of this approach.
- MeSH
- dietní proteiny MeSH
- dietní sacharidy diagnostické užití MeSH
- dietní tuky analýza MeSH
- ketony chemie MeSH
- kyseliny mandlové chemie MeSH
- kyseliny mastné neesterifikované chemie MeSH
- lidé anatomie a histologie psychologie růst a vývoj MeSH
- mastné kyseliny chemie MeSH
- obezita diagnóza farmakoterapie klasifikace metabolismus prevence a kontrola psychologie rehabilitace terapie MeSH
- tělesná hmotnost fyziologie MeSH
- Check Tag
- lidé anatomie a histologie psychologie růst a vývoj MeSH
- ženské pohlaví MeSH
