Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer's disease: corresponding results in real space tests and computer tests
Language English Country Netherlands Media print-electronic
Document type Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
15817181
DOI
10.1016/j.bbr.2004.10.016
PII: S0166-4328(04)00400-0
Knihovny.cz E-resources
- MeSH
- Alzheimer Disease physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Orientation physiology MeSH
- Memory physiology MeSH
- Exploratory Behavior physiology MeSH
- Computer Graphics MeSH
- Memory Disorders physiopathology MeSH
- Attention physiology MeSH
- Spatial Behavior physiology MeSH
- Aged MeSH
- Serial Learning physiology MeSH
- Severity of Illness Index MeSH
- Space Perception physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
Spatial disorientation and learning problems belong to the integral symptoms of Alzheimer's disease (AD). A circular arena for human subjects (2.9 m diameter, 3 m high) was equipped with a computerized tracking system, similar to that used in animals. We studied navigation in 11 subjects diagnosed with early stages of Alzheimer's disease (AD), 27 subjects with subjective problems with memory or concentration, and 10 controls. The task was to locate one or several unmarked goals using the arena geometry, starting position and/or cues on the arena wall. Navigation in a real version and a computer map view version of the tests yielded similar results. The AD group was severely impaired relative to controls in navigation to one hidden goal in eight rotated positions. The impairment was largest when only the cues on the wall could be used for orientation. Also, the AD group recalled worse than controls the order of six sequentially presented locations, though they recalled similarly to controls the positions of the locations. The group with subjective problems was not impaired in any of the tests. Our results document the spatial navigation and non-verbal episodic memory impairment in the AD. Similar results in real and map view computer tests support the use of computer tests in diagnosis of cognitive disturbances.
References provided by Crossref.org
The use of egocentric and allocentric reference frames in static and dynamic conditions in humans
Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer's disease
Spatial navigation impairment is proportional to right hippocampal volume
Spatial navigation deficit in amnestic mild cognitive impairment
