Spatial navigation impairment is proportional to right hippocampal volume
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
F32 NS010331
NINDS NIH HHS - United States
PubMed
22308496
PubMed Central
PMC3289383
DOI
10.1073/pnas.1121588109
PII: 1121588109
Knihovny.cz E-zdroje
- MeSH
- hipokampus anatomie a histologie patologie MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. Among these individuals, deterioration in spatial navigation, manifested by poor hippocampus-dependent allocentric navigation, may occur well before the clinical onset of dementia. Our aim was to determine whether allocentric spatial navigation impairment would be proportional to right hippocampal volume loss irrespective of general brain atrophy. We also contrasted the respective spatial navigation scores of the real-space human Morris water maze with its corresponding 2D computer version. We included 42 cognitively impaired patients with either amnestic mild cognitive impairment (n = 23) or mild and moderate AD (n = 19), and 14 cognitively intact older controls. All participants underwent 1.5T MRI brain scanning with subsequent automatic measurement of the total brain and hippocampal (right and left) volumes. Allocentric spatial navigation was tested in the real-space version of the human Morris water maze and in its corresponding computer version. Participants used two navigational cues to locate an invisible goal independent of the start position. We found that smaller right hippocampal volume was associated with poorer navigation performance in both the real-space (β = -0.62, P < 0.001) and virtual (β = -0.43, P = 0.026) versions, controlling for demographic variables, total brain and left hippocampal volumes. In subsequent analyses, the results were significant in cognitively impaired (P ≤ 0.05) but not in cognitively healthy (P > 0.59) subjects. The respective real-space and virtual scores strongly correlated with each other. Our findings indicate that the right hippocampus plays a critical role in allocentric navigation, particularly when cognitive impairment is present.
Zobrazit více v PubMed
McShane R, et al. Getting lost in dementia: A longitudinal study of a behavioral symptom. Int Psychogeriatr. 1998;10:253–260. PubMed
Pai MC, Jacobs WJ, Int J. Topographical disorientation in community-residing patients with Alzheimer's disease. Int J Geriatr Psychiatry. 2004;19:250–255. PubMed
Hort J, et al. Spatial navigation deficit in amnestic mild cognitive impairment. Proc Natl Acad Sci USA. 2007;104:4042–4047. PubMed PMC
O'Keefe J, Nadel L. The Hippocampus as a Cognitive Map. New York: Oxford Univ Press; 1978.
Maguire EA, et al. Knowing where and getting there: A human navigation network. Science. 1998;280:921–924. PubMed
Packard MG, Knowlton BJ. Learning and memory functions of the basal ganglia. Annu Rev Neurosci. 2002;25:563–593. PubMed
White NM, McDonald RJ. Multiple parallel memory systems in the brain of the rat. Neurobiol Learn Mem. 2002;77:125–184. PubMed
Weniger G, Ruhleder M, Wolf S, Lange C, Irle E. Egocentric memory impaired and allocentric memory intact as assessed by virtual reality in subjects with unilateral parietal cortex lesions. Neuropsychologia. 2009;47:59–69. PubMed
O'Keefe J, Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res. 1971;34:171–175. PubMed
Spiers HJ, et al. Unilateral temporal lobectomy patients show lateralized topographical and episodic memory deficits in a virtual town. Brain. 2001;124:2476–2489. PubMed
deIpolyi AR, Rankin KP, Mucke L, Miller BL, Gorno-Tempini ML. Spatial cognition and the human navigation network in AD and MCI. Neurology. 2007;69:986–997. PubMed
Weniger G, Ruhleder M, Lange C, Wolf S, Irle E. Egocentric and allocentric memory as assessed by virtual reality in individuals with amnestic mild cognitive impairment. Neuropsychologia. 2011;49:518–527. PubMed
Burgess N, Trinkler I, King J, Kennedy A, Cipolotti L. Impaired allocentric spatial memory underlying topographical disorientation. Rev Neurosci. 2006;17:239–251. PubMed
Kalová E, Vlcek K, Jarolímová E, Bures J. Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer's disease: Corresponding results in real space tests and computer tests. Behav Brain Res. 2005;159:175–186. PubMed
Sobel ME. In: Sociological Methodology. Leinhardt S, editor. Washington, DC: Am Soc Assoc; 1982. pp. 290–312.
Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 1982;297:681–683. PubMed
Morris RG. Spatial localization does not require the presence of local cues. Learn Motiv. 1981;12:239–261.
Burgess N, Jeffery KJ, O'Keefe J. The Hippocampal and Parietal Foundations of Spatial Cognition. Oxford: Oxford Univ Press; 1999.
Astur RS, Taylor LB, Mamelak AN, Philpott L, Sutherland RJ. Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task. Behav Brain Res. 2002;132:77–84. PubMed
Petersen RC. Mild cognitive impairment. Continuum (N Y) 2004;10:9–28.
Desikan RS, et al. Alzheimer's Disease Neuroimaging Initiative Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease. Brain. 2009;132:2048–2057. PubMed PMC
Aguirre GK, Detre JA, Alsop DC, D'Esposito M. The parahippocampus subserves topographical learning in man. Cereb Cortex. 1996;6:823–829. PubMed
American Psychiatric Association . 2000. Diagnostic and Statistical Manual of Mental Disorders (Am Psych Assoc, Washington, DC), 4th Ed, text rev.
McKhann G, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:939–944. PubMed
Petersen RC, et al. Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol. 1999;56:303–308. PubMed
Fischl B, et al. Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron. 2002;33:341–355. PubMed
Ségonne F, et al. A hybrid approach to the skull stripping problem in MRI. Neuroimage. 2004;22:1060–1075. PubMed
Fischl B, et al. Automatically parcellating the human cerebral cortex. Cereb Cortex. 2004;14:11–22. PubMed
Morey RA, et al. A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes. Neuroimage. 2009;45:855–866. PubMed PMC
Iaria G, Palermo L, Committeri G, Barton JJ. Age differences in the formation and use of cognitive maps. Behav Brain Res. 2009;196:187–191. PubMed
Moffat SD, Resnick SM. Effects of age on virtual environment place navigation and allocentric cognitive mapping. Behav Neurosci. 2002;116:851–859. PubMed
Astur RS, Tropp J, Sava S, Constable RT, Markus EJ. Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation. Behav Brain Res. 2004;151:103–115. PubMed
Rahman Q, Koerting J. Sexual orientation-related differences in allocentric spatial memory tasks. Hippocampus. 2008;18:55–63. PubMed
Preacher KJ, Hayes AF. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput. 2004;36:717–731. PubMed
Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173–1182. PubMed
MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V. A comparison of methods to test the significance of the mediated effect. Psychol Methods. 2002;7:83–10. PubMed PMC
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease
Moderating effect of cognitive reserve on brain integrity and cognitive performance
Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults
Famous landmark identification in amnestic mild cognitive impairment and Alzheimer's disease
Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer's disease
Spatial navigation in young versus older adults
Spatial navigation-a unique window into physiological and pathological aging