Effect of tick saliva on mechanisms of innate immune response against Borrelia afzelii
Language English Country England, Great Britain Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
17162955
Knihovny.cz E-resources
- MeSH
- Borrelia burgdorferi Group immunology MeSH
- Cytokines metabolism MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Phagocytosis drug effects MeSH
- Immune Tolerance drug effects MeSH
- Ticks chemistry MeSH
- Complex Mixtures toxicity MeSH
- Macrophages drug effects MeSH
- Mice MeSH
- Nitric Oxide metabolism MeSH
- Immunity, Innate drug effects MeSH
- Carbon Radioisotopes MeSH
- Cattle MeSH
- Saliva chemistry MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Cytokines MeSH
- Complex Mixtures MeSH
- Nitric Oxide MeSH
- Carbon Radioisotopes MeSH
The effect of salivary gland extract (SGE) and saliva from the tick Ixodes ricinus (L.) on the interaction of Borrelia afzelii spirochetes with mouse macrophages as well as on the borreli-acidal effect of calf serum was studied. SGE reduced both the number of phagocytosing cells and phagocytosed bacteria. An inhibitory effect of SGE on the killing of spirochetes by the alternative pathway of complement activation also was observed. Both SGE and saliva down-regulated production of proinflammatory cytokine tumor necrosis factor-alpha by macrophages stimulated with interferon-gamma and live B. afzelii spirochetes. The production of another macrophage cytokine, interleukin-6, remained unchanged. SGE and saliva exerted a different effect on the production of nitric oxide by stimulated macrophages. Whereas SGE up-regulated NO production, saliva decreased it. The significance of immunosuppressive effects of tick saliva for the transmission of Borrelia spirochetes is discussed.
Allergic reactions to tick saliva components in zebrafish model
Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement
The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin
Modulation of host immunity by tick saliva
