Functional imaging of the cerebellum and basal ganglia during predictive motor timing in early Parkinson's disease
Language English Country United States Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- Keywords
- Basal ganglia, Parkinson's disease, cerebellum, fMRI, prediction, timing,
- MeSH
- Basal Ganglia physiopathology MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain Mapping methods MeSH
- Motor Skills * MeSH
- Cerebellum physiopathology MeSH
- Nerve Net physiopathology MeSH
- Parkinson Disease physiopathology MeSH
- Movement * MeSH
- Anticipation, Psychological MeSH
- Reaction Time MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
BACKGROUND AND PURPOSE: The basal ganglia and the cerebellum have both emerged as important structures involved in the processing of temporal information. METHODS: We examined the roles of the cerebellum and striatum in predictive motor timing during a target interception task in healthy individuals (HC group; n = 21) and in patients with early Parkinson's disease (early stage PD group; n = 20) using functional magnetic resonance imaging. RESULTS: Despite having similar hit ratios, the PD failed more often than the HC to postpone their actions until the right moment and to adapt their behavior from one trial to the next. We found more activation in the right cerebellar lobule VI in HC than in early stage PD during successful trials. Successful trial-by-trial adjustments were associated with higher activity in the right putamen and lobule VI of the cerebellum in HC. CONCLUSIONS: We conclude that both the cerebellum and striatum are involved in predictive motor timing tasks. The cerebellar activity is associated exclusively with the postponement of action until the right moment, whereas both the cerebellum and striatum are needed for successful adaptation of motor actions from one trial to the next. We found a general ''hypoactivation'' of basal ganglia and cerebellum in early stage PD relative to HC, indicating that even in early stages of the PD there could be functional perturbations in the motor system beyond striatum.
References provided by Crossref.org
The mystery of the cerebellum: clues from experimental and clinical observations
Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study
Neural Network of Predictive Motor Timing in the Context of Gender Differences
The mechanisms of movement control and time estimation in cervical dystonia patients
Essential tremor, the cerebellum, and motor timing: towards integrating them into one complex entity
