Divergent mitochondrial respiratory chains in phototrophic relatives of apicomplexan parasites
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
Canadian Institutes of Health Research - Canada
PubMed
25660376
DOI
10.1093/molbev/msv021
PII: msv021
Knihovny.cz E-resources
- Keywords
- Apicomplexa, Chromera, Vitrella, anaerobic metabolism, evolution, respiratory chain,
- MeSH
- Alveolata genetics metabolism MeSH
- Apicomplexa genetics MeSH
- Cytochromes c metabolism MeSH
- Photosynthesis genetics MeSH
- Phylogeny * MeSH
- Genetic Variation * MeSH
- Genome, Mitochondrial MeSH
- Lactic Acid metabolism MeSH
- Mitochondrial Proton-Translocating ATPases genetics metabolism MeSH
- Mitochondria genetics metabolism MeSH
- Evolution, Molecular * MeSH
- Parasites genetics metabolism MeSH
- Electron Transport Complex I genetics metabolism MeSH
- Electron Transport MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cytochromes c MeSH
- Lactic Acid MeSH
- Mitochondrial Proton-Translocating ATPases MeSH
- Electron Transport Complex I MeSH
Four respiratory complexes and ATP-synthase represent central functional units in mitochondria. In some mitochondria and derived anaerobic organelles, a few or all of these respiratory complexes have been lost during evolution. We show that the respiratory chain of Chromera velia, a phototrophic relative of parasitic apicomplexans, lacks complexes I and III, making it a uniquely reduced aerobic mitochondrion. In Chromera, putative lactate:cytochrome c oxidoreductases are predicted to transfer electrons from lactate to cytochrome c, rendering complex III unnecessary. The mitochondrial genome of Chromera has the smallest known protein-coding capacity of all mitochondria, encoding just cox1 and cox3 on heterogeneous linear molecules. In contrast, another photosynthetic relative of apicomplexans, Vitrella brassicaformis, retains the same set of genes as apicomplexans and dinoflagellates (cox1, cox3, and cob).
References provided by Crossref.org
Mitochondrial genomes revisited: why do different lineages retain different genes?
Organellar Evolution: A Path from Benefit to Dependence
The cell wall polysaccharides of a photosynthetic relative of apicomplexans, Chromera velia
Fatty Acid Biosynthesis in Chromerids
Isolation of plastids and mitochondria from Chromera velia
Characterization of Aminoacyl-tRNA Synthetases in Chromerids
From simple to supercomplex: mitochondrial genomes of euglenozoan protists
Unexpectedly Streamlined Mitochondrial Genome of the Euglenozoan Euglena gracilis
BioProject
PRJEB667, PRJEB6670
SRA
ERR558149, ERR558150, ERR558151, ERR558152, ERR558194, ERR558195, ERR558196, ERR558197, ERR558198, ERR558199, ERR558200, ERR558201, ERR558202, ERR571482, ERR571483, ERR571484, ERR571485
