The effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
30184736
DOI
10.1016/j.msec.2018.06.041
PII: S0928-4931(17)33882-1
Knihovny.cz E-resources
- Keywords
- Ethylene oxide sterilization, Nanofibers, Polyesters, Vascular grafts,
- MeSH
- Biocompatible Materials chemistry metabolism pharmacology MeSH
- Cell Line MeSH
- Blood Vessel Prosthesis MeSH
- Ethylene Oxide chemistry pharmacology MeSH
- Microscopy, Electron, Scanning MeSH
- Elastic Modulus MeSH
- Mice MeSH
- Nanofibers chemistry MeSH
- Tensile Strength MeSH
- Polyesters chemistry metabolism MeSH
- Sterilization MeSH
- Cell Survival drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Ethylene Oxide MeSH
- poly(lactide) MeSH Browser
- polycaprolactone MeSH Browser
- Polyesters MeSH
The study describes the detailed examination of the effect of ethylene oxide sterilization on electrospun scaffolds constructed from biodegradable polyesters. Different fibrous layers fabricated from polycaprolactone (PCL) and a copolymer consisting of polylactide and polycaprolactone (PLCL) were investigated for the determination of their mechanical properties, degradation rates and interaction with fibroblasts. It was discovered that the sterilization procedure influenced the mechanical properties of the electrospun PLCL copolymer scaffold to the greatest extent. No effect of ethylene oxide sterilization on degradation behavior was observed. However, a delayed fibroblast proliferation rate was noticed with concern to the ethylene oxide sterilized samples compared to the ethanol sterilization of the materials.
References provided by Crossref.org
Impact of Various Sterilization and Disinfection Techniques on Electrospun Poly-ε-caprolactone
