Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
36773580
DOI
10.1016/j.ijheh.2023.114119
PII: S1438-4639(23)00010-X
Knihovny.cz E-zdroje
- Klíčová slova
- Adults, Children, Exposure biomarkers, HBM4EU, Human biomonitoring (HBM), Teenagers,
- MeSH
- akrylamidy MeSH
- arsen * analýza MeSH
- biologické markery MeSH
- biologický monitoring MeSH
- dítě MeSH
- fluorokarbony * analýza MeSH
- kadmium analýza MeSH
- látky znečišťující životní prostředí * analýza MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- pesticidy * analýza MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- 3-phenoxybenzoic acid MeSH Prohlížeč
- akrylamidy MeSH
- arsen * MeSH
- biologické markery MeSH
- bisphenol A MeSH Prohlížeč
- fluorokarbony * MeSH
- kadmium MeSH
- látky znečišťující životní prostředí * MeSH
- pesticidy * MeSH
- phthalic acid MeSH Prohlížeč
As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.
Aarhus University Department of Environmental Science Frederiksborgvej 399 4000 Roskilde Denmark
Cyprus State General Laboratory Ministry of Health P O Box 28648 2081 Nicosia Cyprus
Department of Clinical Pharmacology Pharmacy and Environmental Medicine Italy
Department of Environmental Health Ministry of Health Israel
Department of Medicine DAME University of Udine Udine Italy
Dept Pharmacology and Toxicology University of Iceland Reykjavik Iceland
Environment Agency Austria 1090 Vienna Austria
Escola Superior de Tecnologia da Saúde de Lisboa Lisbon Portugal
European Environment Agency Kongens Nytorv 6 1050 Copenhagen K Denmark
Faculty of Food Science and Nutrition University of Iceland Reykjavik Iceland
Finnish Institute for Health and Welfare Kuopio Finland
Finnish Institute of Occupational Health P O Box 40 FI 00032 Työterveyslaitos Finland
German Environment Agency Corrensplatz 1 14195 Dessau Roßlau Germany
Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy
ISGlobal Barcelona Spain; Universitat Pompeu Fabra Spain
Jožef Stefan Institute Department of Environmental Sciences Jamova cesta 39 1000 Ljubljana Slovenia
Luxembourg Institute of Health Luxembourg
Medical University of Vienna ZPH Dept of Environmental Health Austria
Ministry of Health Lisbon Portugal
National Food Institute Technical University of Denmark Denmark
National Public Health Center Budapest Hungary
Nofer Institute of Occupational Medicine Lodz Poland
Norwegian Institute of Public Health Department of Food Safety PO Box 222 Skøyen 0213 Oslo Norway
Oniris INRAE LABERCA Nantes France
Provincial Institute of Hygiene Antwerp Belgium
RECETOX Faculty of Science Masaryk University Kotlarska 2 Brno 611 37 Czech Republic
School for Advanced Study Science Technology and Society Department Pavia Italy
Slovak Medical University Faculty of Public Health Limbová 12 833 03 Bratislava Slovak Republic
Swedish Food Agency Risk Benefit Assessment Department Box 622 SE 751 26 Uppsala Sweden
UKHSA UK Health Security Agency Harwell Science Park Chilton OX11 0RQ United Kingdom
Université Paris Cité Inserm T3S Paris France
University of Antwerp Toxicological Center Universiteitsplein 1 2610 Wilrijk Belgium
VITO Health Flemish Institute for Technological Research Boeretang 200 2400 Mol Belgium
Citace poskytuje Crossref.org
Evidence for widespread human exposure to food contact chemicals
