Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.
- MeSH
- antitumorózní látky * farmakologie terapeutické užití MeSH
- cisplatina dějiny farmakologie terapeutické užití MeSH
- galium dějiny farmakologie terapeutické užití MeSH
- genomika metody trendy MeSH
- individualizovaná medicína metody trendy využití MeSH
- kobalt dějiny farmakologie terapeutické užití MeSH
- komplexní sloučeniny * farmakologie terapeutické užití MeSH
- lidé MeSH
- měď farmakologie terapeutické užití MeSH
- metabolomika metody trendy MeSH
- mezioborová komunikace MeSH
- proteomika metody trendy MeSH
- sloučeniny ruthenia dějiny farmakologie terapeutické užití MeSH
- sloučeniny železa dějiny farmakologie terapeutické užití MeSH
- sloučeniny zlata dějiny farmakologie terapeutické užití MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
The applications of gas plasma and plasma modified materials in the emerging fields of medicine such as dentistry, drug delivery, and tissue engineering. Plasma sterilization of both living and non-living objects is safe, fast and efficient; for example plasma sterilization of medical equipment quickly removes microorganisms with no damage to the tiny delicate parts of the equipment and in dentistry it offers a non-toxic, painless bacterial inactivation of tissues from a dental cavity. Devices that generate plasma inside the root canal of a tooth give better killing efficiency against bacteria without causing any harm to the surrounding tissues. Plasma modified materials fulfill the requirements for bioactivity in medicine; for example, the inclusion of antimicrobial agents (metal nano particles, antimicrobial peptides, enzymes, etc.) in plasma modified materials (polymeric, metallic, etc) alters them to produce superior antibacterial biomedical devices with a longer active life. Thin polymer films or coating on surfaces with different plasma processes improves the adherence, controlled loading and release of drug molecules. Surface functionalization by plasma treatment stimulates cell adhesion, cell growth and the spread of tissue development. Plasma applications are already contributing significantly to the changing face of medicine and future trends are discussed in this paper.
- Klíčová slova
- plasma, sterilization, dentistry, surface functionalization, drug delivery, tissue engineering,
- MeSH
- biokompatibilní materiály MeSH
- biomedicínské inženýrství metody přístrojové vybavení trendy MeSH
- chemické jevy MeSH
- financování organizované MeSH
- kovy terapeutické užití MeSH
- lidé MeSH
- nosiče léků MeSH
- plyny MeSH
- polymery terapeutické užití MeSH
- protézy a implantáty využití MeSH
- slitiny terapeutické užití MeSH
- sterilizace MeSH
- výzkumné techniky MeSH
- zaváděcí katétry využití MeSH
- zubní materiály terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- biomedicínské technologie ekonomika metody trendy MeSH
- buňky chemie účinky léků MeSH
- financování organizované MeSH
- lidé MeSH
- lymfocyty chemie účinky záření MeSH
- mykotoxiny izolace a purifikace toxicita MeSH
- nanomedicína metody přístrojové vybavení trendy MeSH
- nanotechnologie metody přístrojové vybavení trendy MeSH
- nanotrubičky uhlíkové chemie toxicita využití MeSH
- plíce chemie účinky léků MeSH
- reaktivní formy kyslíku škodlivé účinky toxicita MeSH
- testy toxicity metody využití MeSH
- způsoby aplikace léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
The kinetics of acid-catalyzed dissociation of the copper(II) complex with 7-methyl-3,7,11,17-tetraazabicyclo[11.3.1]heptadeca-1(17),13,15-triene-3,11-diacetic acid (ac2Me[14]pyN4) at [H+] = 0.05-0.25 mol l-1, I = 0.25 mol l-1 (Na, H)ClO4, and T = 298.16 K was studied with conventional and stopped-flow UV/VIS spectroscopy. Three steps of consecutive complex reaction were observed. The very fast first and second steps characterized by k1 = 70 ± 10 and k2 = 0.23 ± 0.01 l mol-1 s-1 depend on the H+ concentration. The third step is very slow, k3 = (1.08 ± 0.03) × 10-3 s-1, and does not depend on the H+ concentration. Latter rate-determining step involves an isomerisation process forcing the copper(II) ion to leave rapidly the macrocyclic cavity. The reaction mechanism of the complex dissociation has been proposed, taking into account the results obtained for related systems by independent methods: potentiometry, UV/VIS and EPR spectroscopies, X-ray diffraction analysis, and molecular mechanics calculations.
These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of these, silver nanoparticles are playing a major role in the field of nanotechnology and nanomedicine. Their unique size-dependent properties make these materials superior and indispensable as they show unusual physical, chemical and biological properties. Silver nanoparticles have potential antimicrobial activity towards many pathogenic microbes. Along with this antimicrobial activity, silver nanoparticles are showing unacceptable toxic effects on human health and the environment. The chronic exposure to silver causes adverse effects such as permanent bluish-grey discoloration of the skin (argyria) and eyes (argyrosis). Besides argyria and argyrosis, exposure to soluble silver compounds may produce other toxic effects like liver and kidney damage, irritation of the eyes, skin, respiratory and intestinal tract and changes to blood cells. This review summarizes the hazardous effects of silver nanoparticles in the environment and theirs toxic effects on human health.
- MeSH
- antiinfekční látky terapeutické užití toxicita MeSH
- argyrie etiologie imunologie metabolismus MeSH
- financování organizované MeSH
- kovové nanočástice škodlivé účinky toxicita MeSH
- lidé MeSH
- nanomedicína metody trendy MeSH
- nanotechnologie metody trendy MeSH
- sloučeniny stříbra škodlivé účinky toxicita MeSH
- stříbro škodlivé účinky toxicita MeSH
- toxické účinky metabolismus škodlivé účinky MeSH
- znečištění životního prostředí škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
The reaction of P3N3Cl6 (1) with heptamethyldisilazane in the molar ratio 1:1 leads to the formation of 2,4,4,6,6-pentachloro-N-methyl-N-(trimethylsilyl)cyclotriphosphazen-2-amine, P3N3Cl5{N(CH3)[Si(CH3)3]} (2). Compound 2 was characterized by elemental analysis and spectroscopically. Molecular and crystal structures of 2 were determined by X-ray diffraction. 2 is monoclinic, space group P21/n. Experimental data were compared with results of DFT calculations.
