The authors compare data of patients with malignant melanoma in 1970 -1972, 1980 -1982 and 1990 -1992. They evaluated differences as regards sex, site, type of tumour and course of the disease. As compared with the seventies, in the nineties the increment of new cases was more than double. In the seventies and eighties men predominated (52 - 54 %), in the nineties there was a higher incidence of melanoma in women (59 %). In the seventies the most frequent site of the tumour were the lower extremities (33 %), while in the nineties it was the back (34 %). In the seventies the authors recorded tumourous duplicity in 6.8 % of the patients, in the nineties in 19 % of patients, more frequently in women.
- MeSH
- lidé MeSH
- melanom MeSH
- prevalence MeSH
- životní prostředí MeSH
- Check Tag
- lidé MeSH
A 50-year-old man developed within a short time sclerodermiform changes on the upper half of the body associated with considerable loss of pubescence. Examination revealed high uroporphyrin levels and the diagnosis of porphyria cutanea tarda associated with this dermatological symptomatology was diagnosed. Organ damage, suggesting systemic scleroderma was not found. After venepuncture and combined treatment with anti-malaria drugs, penicillin and small doses of steroids sclerotization of the skin receded substantially within a short time, pubescence reappeared and the porphyrin values reached normal levels.
- MeSH
- dospělí MeSH
- lidé MeSH
- porphyria cutanea tarda patologie MeSH
- systémová sklerodermie patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
In a 77-year-old man with systemic amyloidosis in the course of two-year follow-up mucosal and skin complaints dominated without symptoms of visceral affection. Treatment with a combination of prednisone, imuran, colchicin and d-penicillamine did not lead to improvement of the complaints. onths before sudden death of the patient CT revealed a tumour in the urinary bladder which on necropsy was diagnosed as transitional-cell carcinoma. No metastases were found. Necropsy revealed also generalized amyloidosis with a significant affection of the heart muscle which was the cause of death.
- MeSH
- acne vulgaris farmakoterapie patologie MeSH
- benzoylperoxid terapeutické užití MeSH
- erythromycin terapeutické užití MeSH
- isotretinoin terapeutické užití MeSH
- klindamycin terapeutické užití MeSH
- kombinovaná farmakoterapie metody MeSH
- lidé MeSH
- tretinoin terapeutické užití MeSH
- Check Tag
- lidé MeSH
