DD genotype of ACE gene is a predisposing factor for chronic kidney disease terminating nephrotic syndrome in children with type 1 diabetes mellitus, while ACE gene II genotype upon diabetic nephropathy appears to be a protective one. The work was initiated to assess efficacy of perindopril in normoalbuminuric patients with type 1 diabetes mellitus by ACE genotype in the primary intervention of diabetic nephropathy. 22 normoalbuminuric patients with type 1 diabetes mellitus aged from 12 to 70 with diabetic nephropathy duration of 10 and more years were examined to be divided into two groups by ACE polymorphism including eleven-by-eleven carriers of II genotype and DD genotype, respectively. Perindopril in low doses is recommended to treat normoalbuminuric children and adolescents for optimization of intervention and therapy of diabetic nephropathy.

• MeSH
• antihypertenziva aplikace a dávkování   terapeutické užití   MeSH
• diabetes mellitus 1. typu * farmakoterapie   genetika   MeSH
• diabetické nefropatie * farmakoterapie   genetika   prevence a kontrola   MeSH
• dítě MeSH
• genotyp MeSH
• inhibitory ACE * aplikace a dávkování   terapeutické užití   MeSH
• ledviny účinky léků   MeSH
• lidé MeSH
• mladiství MeSH
• výsledek terapie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

Today obesity is a global epidemic and children are the worst affected. Waist circumference (WC), waist-hip ratio (WHR) and waist-to-height ratio (WHTR) are the anthropometric indices characterizing central obesity in children, but WC measurement in children is not a routine practice. In the International Diabetes Federation recommendations WC value is offered as a criterion for the metabolic syndrome diagnosis in children instead of body mass index. The work was initiated to determine age- and sex-specific WC reference values in 7-18 year old Uzbek children and adolescents, residents of Tashkent, capital of Uzbekistan.

• MeSH
• antropometrie MeSH
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• obvod pasu * MeSH
• poměr pasu a boků * MeSH
• statistika jako téma MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Uzbekistán MeSH