Článek formou přehledu shrnuje soudobý pohled na základní principy patofyziologie, diagnostiky a léčby traumatem indukované koagulopatie u pacientů se závažným úrazem.
This narrative review article summarizes the contemporary view on the basic principles of pathophysiology, diagnosis and treatment of trauma-induced coagulopathy in patients with severe trauma.
Shock index (a ratio between heart rate and systolic blood pressure) predicts transfusion requirements and the need for haemostatic resuscitation in severe trauma patients. In the present study, we aimed to determine whether prehospital and on-admission shock index values can be used to predict low plasma fibrinogen in trauma patients. Between January 2016 and February 2017, trauma patients admitted from the helicopter emergency medical service into two large trauma centres in the Czech Republic were prospectively assessed for demographic, laboratory and trauma-associated variables and shock index at scene, during transport and at admission to the emergency department. Hypofibrinogenemia defined as fibrinogen plasma level of 1.5 g·L-l was deemed as a cut-off for further analysis. Three hundred and twenty-two patients were screened for eligibility. Of these, 264 (83%) were included for further analysis. The hypofibrinogenemia was predicted by the worst prehospital shock index with the area under the receiver operating characteristics curve (AUROC) of 0.79 (95% CI 0.64-0.91) and by the admission shock index with AUROC of 0.79 (95% CI 0.66-0.91). For predicting hypofibrinogenemia, the prehospital shock index ≥ 1 has 0.5 sensitivity (95% CI 0.19-0.81), 0.88 specificity (95% CI 0.83-0.92) and a negative predictive value of 0.98 (0.96-0.99). The shock index may help to identify trauma patients at risk of hypofibrinogenemia early in the prehospital course.
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- humanitární jednotky, příprava, vzdělávání, zážitková pedagogika,
- MeSH
- Červený kříž MeSH
- cvičení MeSH
- first responder výchova MeSH
- hromadné neštěstí mortalita prevence a kontrola MeSH
- lidé MeSH
- pomoc v nouzi organizace a řízení MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Rakousko MeSH
