OBJECTIVES: Little is known about the role of adipokines in the pathogenesis of coronary artery disease in young patients. The aims of this study were to compare serum levels of adipokines and expression of adipokines in peripheral blood leukocytes in patients with premature coronary artery disease (CAD), metabolic syndrome and healthy individuals. DESIGN AND METHODS: Sixty-five patients with premature CAD (men 18-45years old and women 18-55years old) formed the study group. The control groups were 75 patients with metabolic syndrome and 50 healthy individuals. For each group, RNA expression in peripheral blood leukocytes was determined for 24 different adipokines and 11 adipokines were examined in serum. RESULTS: In individuals with CAD, serum visfatin levels were significantly higher than in metabolic syndrome and healthy controls (2.3 vs. 1.6 vs. 0.7µg/L, P<0.001) while both omentin-1 (92.9 vs. 587.0 vs. 552.3µg/L, P<0.001) and ZAG2 (45.5 vs. 72.5 vs. 77.1mg/L, P<0.001) levels were lower. The receiver operating curve (ROC) analysis for testing the validity of these adipokines in the diagnosis of CAD compared to control groups provided the following areas under the curve (AUC): omentin-1 AUC 0.97 (cut-off ≤222µg/L), ZAG2 AUC 0.89 (cut-off ≤51.7mg/L) and visfatin AUC 0.74 (cut-off ≥1.0µg/L) (P<0.001 in all cases). Visfatin and omentin-1 serum levels did not differ between the acute phase of myocardial infarction and the chronic phase of CAD. In patients with CAD, we found no significant relation between mRNA expression and adipokine concentration. CONCLUSION: Serum omentin-1, visfatin and ZAG2 could serve as biomarkers of premature CAD in young apparently healthy people.
- MeSH
- adipokiny krev genetika metabolismus MeSH
- cytokiny krev genetika MeSH
- dospělí MeSH
- GPI-vázané proteiny krev genetika MeSH
- infarkt myokardu krev genetika MeSH
- kohortové studie MeSH
- lektiny krev genetika MeSH
- leukocyty metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA krev MeSH
- metabolický syndrom krev genetika MeSH
- mladiství MeSH
- nemoci koronárních tepen krev genetika MeSH
- nikotinamidfosforibosyltransferasa krev genetika MeSH
- podkožní tuk metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Adipokines are peptides that signal the functional status of adipose tissue to the brain and other target organs. In adipose tissue dysfunction, adipokine secretion is altered, and this can contribute to a spectrum of obesity-associated conditions including cardiovascular disease. Some adipokines have anti-inflammatory and cardioprotective effects (omentin, apelin, adiponectin). Others are pro-inflammatory with negative impact on cardiovascular function (leptin, visfatin, resistin, adipocyte fatty-acid-binding protein). In the first part, this article reviews the endocrine functions of adipose tissue in general, effects of the distribution and composition of fat tissue, and the roles of cortisol and the renin-angiotensin-aldosterone system in the development of the inflammatory state of addipose tissue. In the second part, the known cardiovascular effects of different adipokines and their clinical potential are discussed in detail.
- MeSH
- adipokiny fyziologie sekrece MeSH
- C-reaktivní protein fyziologie MeSH
- distribuce tělesného tuku MeSH
- hydrokortison fyziologie MeSH
- inzulinová rezistence fyziologie MeSH
- kardiovaskulární nemoci etiologie MeSH
- lidé MeSH
- obezita komplikace MeSH
- panniculitis etiologie MeSH
- proteiny vázající mastné kyseliny MeSH
- proteiny vázající retinol fyziologie MeSH
- renin-angiotensin systém fyziologie MeSH
- serpiny fyziologie MeSH
- tuková tkáň chemie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
