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Saturated fatty acid (SFA) intake is associated with obesity, insulin resistance, and hepatic steatosis, but scant work examines the impact of SFA type upon these outcomes. We tested the hypothesis that an obesogenic diet prepared with medium chain SFA (MCSFA), mostly as lauric acid-derived from coconut oil, reduces obesity-induced outcomes compared to obesogenic diets prepared with increasing amounts long chain SFA (LCSFA), primarily palmitic acid. Mice were fed (16 weeks) a control, low fat diet or obesogenic diets prepared with differing content of MCSFA or LCSFA in which polyunsaturated and monounsaturated fatty acids (PUFA; MUFA) were kept constant. Inclusion of MCSFA in an obesogenic diet prevented hepatic lipid accumulation and lowered indices of insulin resistance. Obesogenic diets reduced hepatic levels of de novo lipogenesis proteins (SCD1 and FASN) but elevated the adipose levels of mRNA for the pro-inflammatory markers Mcp-1 and Tnfα. Lipidomic analysis of plasma indicated that MCSFA intake resulted in a different lipidomic signature than LCSFA intake, prevented elevation of pro-inflammatory ceramides, but elevated concentrations of some lipids associated with elevated cardiovascular disease risk. Intake of the obesogenic diets in an SFA-type dependent manner elevated plasma concentrations of several phosphatidylcholine (PC) lipids having the long chain PUFA (LCPUFA) arachidonic acid (ARA) and docosahexaenoic acid (DHA), altered phospholipid ethers, and changed the triacylglyceryl environments of these LCPUFA. Our data indicate that (1) MCSFA reduce the severity of some obesogenic co-morbidities, (2) SFA-type modulates lipidomic signatures associated with cardiovascular disease and diabetes, and (3) dietary SFA type impacts LCPUFA metabolism.

MeSH
ceramidy metabolismus MeSH
hepatitida etiologie MeSH
inzulinová rezistence MeSH
kyseliny mastné mononenasycené farmakologie MeSH
lipidy krev MeSH
lipogeneze účinky léků MeSH
mastné kyseliny chemie metabolismus farmakologie MeSH
myši inbrední C57BL MeSH
obezita etiologie metabolismus MeSH
panniculitis etiologie prevence a kontrola MeSH
zvířata MeSH
Check Tag
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
Research Support, U.S. Gov't, Non-P.H.S. MeSH

Kapitola

Panikulitidy

Alexandrová, Pavla
Autor Alexandrová, Pavla Dermatovenerologická klinika 2. lékařské fakulty Univerzity Karlovy a Nemocnice Na Bulovce, Praha dclinic, dermatologická klinika, Praha

Klinická dermatovenerologie. 2019 ; () : 423-429.

ISBN 978-80-204-5321-1
Medvik
Zdroj

Článek online

Panniculitis-like T-cell-lymphoma in the mesentery associated with hemophagocytic syndrome: autopsy case report

Diagnostic pathology. 2019 ; 14 (1) : 80. [pub] 20190717

Diagn Pathol
ISSN 1746-1596
Medvik
Zdroj

BACKGROUND: Panniculitis-like T-cell lymphoma is an uncommon type of non-Hodgkin lymphoma, occurring usually in the form of nodules within the subcutaneous fat tissue of the extremities or trunk. In the literature, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is described as a distinct type of T-cell lymphoma with a variable clinical behavior, depending on molecular phenotype of T-cell receptor (TCR) and on the presence or absence of hemophagocytic syndrome. CASE PRESENTATION: We present a bioptic and autoptic case of a 65-years old Caucasian man with panniculitic T-cell lymphoma with morphological and immunohistochemical features of SPTCL, limited to the retroperitoneal and mesenteric mass, i.e. without any cutaneous involvement, and associated with severe hemophagocytic lymphohistiocytosis. CONCLUSION: A panniculitic T-cell lymphoma with morphological and molecular features of SPTCL, which is limited to mesentery, i.e. does not involve subcutaneous fat, seems to be exceedingly rare.