The founder of physiology studies in the Balkans and the pioneer of research on hypothermia, Ivan Djaja (Jean Giaja) was born 1884 in L'Havre. Giaja gained his PhD at the Sorbonne in 1909. In 1910 he established the first Chair of Physiology in the Balkans and organized the first Serbian Institute for Physiology at the School of Philosophy of the University of Belgrade. He led this Institute for more than 40 subsequent years. His most notable papers were in the field of thermoregulation and bioenergetics. Djaja became member of the Serbian and Croatian academies of science and doctor honoris causa of Sorbonne. In 1952 for the seminal work on the behavior of deep cooled warm blooded animals he became associate member of the National Medical Academy in Paris. In 1955 the French Academy of Sciences elected him as associate member in place of deceased Sir Alexander Fleming. Djaja died in 1957 during a congress held in his honor. He left more than 200 scientific and other papers and the golden DaVincian credo "Nulla dies sine experimento". His legacy was continued by several generations of researchers, the most prominent among them being Stefan Gelineo, Radoslav Andjus and Vojislav Petrović.
- MeSH
- dějiny lékařství MeSH
- energetický metabolismus fyziologie MeSH
- fyziologie dějiny MeSH
- hypotermie MeSH
- lidé MeSH
- neuroendokrinní buňky fyziologie metabolismus MeSH
- statistika jako téma MeSH
- termoregulace fyziologie MeSH
- univerzity MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- biografie MeSH
- historické články MeSH
- Geografické názvy
- Jugoslávie MeSH
- Srbsko MeSH
This paper highlights some of the key technologies of using two innovative molecular imaging modalites, magnetic resonance imaging (MRI) and nonlinear optical microscopy, for imaging intravenously injected ultra small paramagnetic iron oxide nanoparticles cross linked with antibodies (CLUSPIO) in the amyotrophic lateral sclerosis (ALS) experimental model in vivo or ex vivo, respectively. Intensive efforts have been made in investigating the causes of abnormalities in lipid metabolism, monitored in some neurodegenerative disorders systems. It has been shown that an abnormal accumulation of some common lipids in motor nerve cells may play a critical role in the development of amyotrophic lateral sclerosis. The presented experiments were performed on brain specimens from the transgenic rat model expressing multiple copies of mutated (G93A) human SOD-1 gene, after CD4+ lymphocytes were magnetically labeled with i.v.i. CLUSPIO antibodies. In vivo MRI revealed marked signal intensity enhancements in specific pathological regions of the ALS rat brain as compared to the wild type. Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) microscopy indicated cellular interactions based on lipids association to anti-CD4 CLUSPIO
- MeSH
- amyotrofická laterální skleróza diagnóza etiologie MeSH
- antigeny CD4 diagnostické užití metabolismus MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- lymfocyty fyziologie metabolismus patologie MeSH
- magnetická rezonanční tomografie metody přístrojové vybavení využití MeSH
- metabolismus lipidů MeSH
- mikroskopie metody přístrojové vybavení využití MeSH
- molekulární zobrazování metody využití MeSH
- nanočástice diagnostické užití MeSH
- neurodegenerativní nemoci diagnóza etiologie MeSH
- potkani Sprague-Dawley MeSH
- potkani transgenní MeSH
- Ramanova spektroskopie metody MeSH
- sloučeniny železa diagnostické užití MeSH
- statistika jako téma MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
