BACKGROUND: Biological aging is a physiological process that can be altered by various factors. The presence of a chronic metabolic disease can accelerate aging and increase the risk of further chronic diseases. The aim of the study was to determine whether the presence of metabolic syndrome (MetS) affects levels of markers that are associated with, among other things, aging. MATERIAL AND METHODS: A total of 169 subjects (58 with MetS, and 111 without metabolic syndrome, i.e., non-MetS) participated in the study. Levels of telomerase, GDF11/15, sirtuin 1, follistatin, NLRP3, AGEs, klotho, DNA/RNA damage, NAD+, vitamin D, and blood lipids were assessed from blood samples using specific enzyme-linked immunosorbent assay (ELISA) kits. RESULTS: Telomerase (p < 0.01), DNA/RNA damage (p < 0.006) and GDF15 (p < 0.02) were higher in MetS group compared to non-MetS group. Only vitamin D levels were higher in the non-MetS group (p < 0.0002). Differences between MetS and non-MetS persons were also detected in groups divided according to age: in under 35-year-olds and those aged 35-50 years. CONCLUSIONS: Our results show that people with MetS compared to those without MetS have higher levels of some of the measured markers of biological aging. Thus, the presence of MetS may accelerate biological aging, which may be associated with an increased risk of chronic comorbidities that accompany MetS (cardiovascular, inflammatory, autoimmune, neurodegenerative, metabolic, or cancer diseases) and risk of premature death from all causes.
- Publikační typ
- časopisecké články MeSH
Autoři popisují případ 38letého pacienta s vyvýšeným mokvajícími ložisky v axilách a erozemi v dutině ústní s přesahem na rty. Vyšetření histopatologické a přímou imunofluorescencí potvrdilo diagnózu pemphigus vegetans. Článek shrnuje informace o diagnostice a léčbě tohoto onemocnění.
The authors describe the case of a 38-year-old patient with elevated oozing plaques in the axillae and erosions in the oral cavity and on the lips. Histopathological and direct immunofluorescence examination confirmed the diagnosis of pemphigus vegetans. The article summarizes information on diagnosis and treatment of this disorder.
- Klíčová slova
- pemphigus vegetans,
- MeSH
- axila anatomie a histologie patologie MeSH
- dospělí MeSH
- kožní nemoci diagnóza farmakoterapie MeSH
- lidé MeSH
- pemfigus * diagnóza farmakoterapie MeSH
- prednison aplikace a dávkování terapeutické užití MeSH
- ústa patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
