Wound healing is a very complex process, where variety of different pathways is activated, depending on the phase of healing. Improper or interrupted healing might result in development of chronic wounds. Therefore, novel approaches based on detailed knowledge of signalling pathways that are activated during acute or chronic cutaneous wound healing enables quicker and more effective healing. This review outlined new possibilities of cutaneous wound healing by modulation of some signalling molecules, e.g., gasotransmitters, or calcium. Special focus is given to gasotransmitters, since these bioactive signalling molecules that can freely diffuse into the cell and exert antioxidative effects. Calcium is an important booster of immune system and it can significantly contribute to healing process. Special interest is given to chronic wounds caused by diabetes mellitus and overcoming problems with the inflammation.
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Biogenic amines are low-molecular-weight nitrogen compounds that are formed primarily by the decarboxyla-tion of amino acids by microbial enzymes. These active substances are found mainly in various types of food or beverages. At certain concentrations, biogenic amines are essential for many physiological functions but toxic if consumed in large quantities. Therefore, the development and optimization of methods sensitive to determine these substances are very much needed. The determination of biogenic amines in food and beverages by the most com-monly used separation methods with different types of detection is covered in this review.
Avenanthramides are biologically active substances of phenolic nature. They are present exclusively in oats where, however, their concentrations are relatively high (200 mg kg–1). Three of avenanthramides are mostly repre-sented in the oat grains: N-[3ʹ,4ʹ-dihydroxy-(E)-cinnamoyl]--5-hydroxyanthranilic acid (2c), N-[4ʹ-hydroxy-(E)-cinna-moyl]-5-hydroxyanthranilic acid (2p) and N-[4ʹ-hydroxy- -3ʹmethoxy-(E)-cinnamoyl]-5-hydroxyanthranilic acid (2f). Avenanthramides have significant biological effects, espe-cially antioxidative, but are also interesting due to the ben-eficial effects in oncological diseases, in the process of atherosclerosis, inflammation, diabetes mellitus or derma-tological diseases. Their interesting properties may lead to the inclusion of them in potential therapeutic drugs in the future. For this reason, the need of a study of avenan-thramides as well as of the methods of their determination is increasing. In the article we provide an overview of the latest trends in the extraction and determination of avenan-thramides.
- Klíčová slova
- avenantramidy,
- MeSH
- antioxidancia * MeSH
- arterioskleróza prevence a kontrola MeSH
- farmakokinetika MeSH
- lidé MeSH
- nádory prevence a kontrola MeSH
- oves MeSH
- polyfenoly * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- Helicobacter pylori MeSH
- infekce onkogenními viry MeSH
- infekce vyvolané Helicobacter pylori MeSH
- karcinogeny MeSH
- klinická studie jako téma MeSH
- kontaminace léku MeSH
- lidé MeSH
- nádory etiologie MeSH
- onkogenní viry MeSH
- potravinářský průmysl pracovní síly MeSH
- Retroviridae MeSH
- transplantace škodlivé účinky MeSH
- vakcíny škodlivé účinky MeSH
- zoonózy * epidemiologie prevence a kontrola MeSH
- Check Tag
- lidé MeSH
- MeSH
- kontrola potravin trendy MeSH
- zákonodárství potravinářské MeSH
- Geografické názvy
- Slovenská republika MeSH
