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69 záznamů v Medvik Filtry

Článek

Epstein-Barr Virus and the Pathogenesis of Diffuse Large B-Cell Lymphoma

Ross, Aisling M
Autor Ross, Aisling M ORCID Health Research Institute and School of Medicine, University of Limerick, V94 T9PX Limerick, Ireland BioScience and BioEngineering Research (BioSciBer), Bernal BioMaterials Cluster, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
Leahy, Ciara I
Autor Leahy, Ciara I Health Research Institute and School of Medicine, University of Limerick, V94 T9PX Limerick, Ireland BioScience and BioEngineering Research (BioSciBer), Bernal BioMaterials Cluster, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
Neylon, Fiona
Autor Neylon, Fiona Health Research Institute and School of Medicine, University of Limerick, V94 T9PX Limerick, Ireland BioScience and BioEngineering Research (BioSciBer), Bernal BioMaterials Cluster, Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland
Steigerova, Jana
Autor Steigerova, Jana Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olmouc, 775 15 Olomouc, Czech Republic
Flodr, Patrik
Autor Flodr, Patrik Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olmouc, 775 15 Olomouc, Czech Republic Department of Clinical and Molecular Pathology, University Hospital Olomouc, 779 00 Olomouc, Czech Republic
Navratilova, Martina
Autor Navratilova, Martina Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olmouc, 775 15 Olomouc, Czech Republic Department of Clinical and Molecular Pathology, University Hospital Olomouc, 779 00 Olomouc, Czech Republic
Urbankova, Helena
Autor Autorita ORCID Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacky Univesity and University Hospital Olomouc, 779 00 Olomouc, Czech Republic
Vrzalikova, Katerina
Autor Vrzalikova, Katerina Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK
Mundo, Lucia
Autor Mundo, Lucia Health Research Institute and School of Medicine, University of Limerick, V94 T9PX Limerick, Ireland Department of Medical Biotechnologies, Section of Pathology, University of Siena, 53100 Siena, Italy
Lazzi, Stefano
Autor Lazzi, Stefano Department of Medical Biotechnologies, Section of Pathology, University of Siena, 53100 Siena, Italy

Life. 2023 ; 13 (2) : . [pub] 20230214

Life (Basel)
ISSN 2075-1729
Medvik
Zdroj

Epstein-Barr virus (EBV), defined as a group I carcinogen by the World Health Organization (WHO), is present in the tumour cells of patients with different forms of B-cell lymphoma, including Burkitt lymphoma, Hodgkin lymphoma, post-transplant lymphoproliferative disorders, and, most recently, diffuse large B-cell lymphoma (DLBCL). Understanding how EBV contributes to the development of these different types of B-cell lymphoma has not only provided fundamental insights into the underlying mechanisms of viral oncogenesis, but has also highlighted potential new therapeutic opportunities. In this review, we describe the effects of EBV infection in normal B-cells and we address the germinal centre model of infection and how this can lead to lymphoma in some instances. We then explore the recent reclassification of EBV+ DLBCL as an established entity in the WHO fifth edition and ICC 2022 classifications, emphasising the unique nature of this entity. To that end, we also explore the unique genetic background of this entity and briefly discuss the potential role of the tumour microenvironment in lymphomagenesis and disease progression. Despite the recent progress in elucidating the mechanisms of this malignancy, much work remains to be done to improve patient stratification, treatment strategies, and outcomes.