Ako retronychia sa označuje zarastanie proximálnej časti nechtovej platničky do proximálneho nechtového valu. Prítomná je xantonychia, stenčenie proximálnej časti nechtovej platničky, pod ktorou vyrastá nová nechtová platnička. K týmto zmenám dochádza najčastejšie vplyvom mikrotraumatizácie. Diagnostika je poväčšine založená na klinickom obraze, v prípade nejasností býva nápomocné ultrasonografické vyšetrenie. Liečba závisí od štádia a závažnosti ochorenia v čase stanovenia diagnózy. Pri ľahkých formách možno použiť konzervatívnu liečbu, a to formou aplikácie kortikosteroidov lokálne, intralezionálne alebo v kombinácii s podologickým ošetrením. Pri pokročilom postihnutí je potrebná avulzia nechtovej platničky. Znalosť príznakov tohto ochorenia a včasná diagnostika umožní aj včasné liečenie, čím je možné predchádzať možným komplikáciám či recidívam.
Retronychia is defined as ingrowth of the proximal nail plate into the proximal nail fold, with the appearance of xantonychia, proximal part of the nail plate is thinned, and a new nail plate is growing below the old one. These changes occur most often as a result of microtraumatisation. The diagnoses is mostly based on the clinical finding and in case of ambiguities, an ultrasonographic examinantion can be helpful. Treatment depends on the stage and severity of the disease at the time of diagnosis. In mild forms it is possible to use conservative treatment, either in the form of applying corticosteroids locally, intralesionally, or in combination with podiatric treatment. In advanced involvement is necessery an avulsion of the nail plate. Knowledge of the symptoms of this disease and its early diagnosis will enable early treatment, which can prevent possible complications or recurrences.
Očné prejavy syfilitickej infekcie sú pomerne zriedkavým nálezom. Autori prezentujú 4 prípady očného postihnutia u pacientov so syfilisom. Prejavy sa manifestovali v dvoch prípadoch ako granulomatózna panuveitída, 1x ako intrabulbárna neuritída n. opticus a 1x ako vitritída s edémom n. opticus. Všetci pacienti mali pozitivitu FTA-ABS IgG testu v likvore. Vo všetkých prípadoch sa nález po liečbe upravil. U všetkých pacientov sa jednalo o sekundárne štádium syfilisu. Autori upozorňujú na riziká nedostatočnej diagnostiky očného postihnutia. Súčasne zdôrazňujú potrebu medziodborovej spolupráce dermatovenerológa, oftalmológa a neurológa.
Ocular manifestations of syphilitic infection are a relatively rare finding. The authors present 4 cases of ocular involvement in patients with syphilis. The granulomatous panuveitis was the manifestation in two cases, one case manifested as the intrabulbar neuritis of the n. opticus and the other one as the vitritis with n. opticus oedema. There was positivity of the FTA-ABS IgG test in the cerebrospinal fluid in all patiens. All cases were diagnosed with secondary stage of syphilis and the findings regressed in all patients after the treatment. The authors call attention to the risks of underdiagnosed ocular impairment, as well as the need of interdisciplinary and collaborative teamwork of dermatovenerologist, ophthalmologist and neurologist.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- neurosyfilis * diagnóza komplikace terapie MeSH
- panuveitida diagnóza etiologie terapie MeSH
- peniciliny farmakologie terapeutické užití MeSH
- syfilis * diagnóza komplikace terapie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
IgA lineárna dermatóza je raritná autoimunitne mediovaná dermatóza postihujúca kožu a sliznice s tvorbou subepidermálne uloženej buly. Autori popisujú prípad výskytu IgA lineárnej dermatózy v súvislosti s očkovaním SARS COV 2 mRNA vakcínou, ktorá bola verifikovaná histologickým a imunohistochemickým vyšetrením.
Linear IgA dermatosis is rare autoimmune mediated dermatosis that affect skin and mucous membranes , and its characterised by formation of subepidermal blisters. The autors present one case of linear IgA dermatosis assosiated with SARS COV-2 mRNA vaccination, diagnosis was made according to histological and imunohistochemical examination.
- MeSH
- dospělí MeSH
- histologické techniky MeSH
- hormony kůry nadledvin aplikace a dávkování terapeutické užití MeSH
- lidé MeSH
- lineární IgA bulózní dermatóza * diagnóza etiologie farmakoterapie MeSH
- methylprednisolon aplikace a dávkování terapeutické užití MeSH
- mRNA vakcíny škodlivé účinky MeSH
- vakcína BNT162 škodlivé účinky MeSH
- vakcíny proti COVID-19 škodlivé účinky MeSH
- vezikulobulózní nemoci kůže etiologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Importance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide. Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics. Design, Setting, and Participants: Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience). Main Outcomes and Measures: In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree. Results: Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients. Conclusions and Relevance: In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.
- MeSH
- dítě MeSH
- dospělí MeSH
- konsensus MeSH
- kyselina listová MeSH
- lidé MeSH
- methotrexát * MeSH
- průzkumy a dotazníky MeSH
- psoriáza * terapie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Vírusové exantémy sú dermatológom známe. Pandémia spôsobená koronavírusom (SARS-CoV-2) s miliónmi infikovaných pacientov postupne odhaľuje široké spektrum pľúcnych i mimopľúcnych manifestácií. Dermatologické manifestácie možno rozdeliť do 6 skupín: urtikariálne prejavy, konfluujúci erytemato-makulo-papulo-morbiliformný exantém, papulovezikulózny exantém, akrálny exantém charakteru pseudoomrzliny, livedo a purpura/vaskulitída. Článok sumarizuje aktuálne poznatky týkajúce sa incidencie, morfológie a vzťahu exantémov k priebehu a závažnosti infekcie COVID-19.
Viral rashes are well-known group in dermatology. Coronavirus-2 (SARS-CoV-2) pandemy affecting millions of people revealed large spectrum pulmonal and extrapulmonal symptoms. Dermatologic manifestations could be divided into 6 groups: urticarial rash, confluent erythematous/maculopapular/morbilliform rash, papulovesicular exanthem, chilblain-like acral pattern, livedo reticularis/racemosa-like pattern and purpuric "vasculitic" pattern. Paper summarizes current knowledges with respect to incidence, clinical picture a relationship of rashes to the course and severity of COVID-19 infection.
- MeSH
- COVID-19 * komplikace MeSH
- exantém etiologie patofyziologie MeSH
- kožní manifestace MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- dermatitida z povolání * etiologie prevence a kontrola MeSH
- kontaktní dermatitida etiologie prevence a kontrola MeSH
- lidé MeSH
- nemoci z povolání prevence a kontrola MeSH
- svrab MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Slovenská republika MeSH
- MeSH
- dermatofibrosarkom * MeSH
- lidé MeSH
- maligní fibrózní histiocytom * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
