Terminalia spp. (čeleď Combretaceae) jsou léčivé rostliny se širokým spektrem léčivých vlastností. Plody Terminalia chebula jsou použí-vány jako tradiční léčivo v asii, zejména v indii. tyto rostliny obsahují různé sekundární metabolity, jako jsou hydrolyzovatelné taniny, fenolické sloučeniny, terpenoidy a flavonoidy, takže se mohou ukázat jako dobrá terapeutická alternativa. Zatím byl prokázán účinek antidiabetický, hypolipidemický, protinádorový, antimutagenní, imunomodulační, antimikrobiální, hepatoprotektivní, gastroprotektiv-ní, antioxidační a antivirový. extrakt z T. chebula také urychluje hojení ran. středem pozornosti jsou i neuroprotektivní, antidepresivní a anxiolytické účinky. Zatím však jsou extrakty těchto rostlin testovány jen na laboratorních zvířatech a chybí klinické testy, které by prokázaly jejich účinek u lidí.
The Terminalia spp. (family Combretaceae) are medicinal plants with a wide spectrum of medicinal properties. the fruits of Terminalia chebula are used as a traditional medicine in asia, especially in india. these plants contain various phytochemicals such as hydrolysable tannins, phenolic compounds, terpenoids, and flavonoids, so it may prove to be a good therapeutic alternative. anti-diabetic, hypoli-pidemic, antitumor, antimutagenic, immunomodulatory, antimicrobial, hepatoprotective, gastroprotective, antioxidant, and antiviral effects have been demonstrated. the extract from T. chebula also accelerates wound healing. neuroprotective, antidepressant and anxio-lytic effects are the center of attention. so far, the extracts of these plants are tested only on laboratory animals and clinical trials are still lacking to demonstrate their effects in humans
Fruit of Terminalia chebula Retz. (Combretaceae) has male contraceptive folk medicine reputation but its molecular aspect regarding hypotesticular activity is still in dark. The study focused the hypotesticular efficacy of the most potent fraction out of n-hexane, chloroform and ethyl acetate fractions of hydro-methanolic (3:2) extract of Terminalia chebula in connection with male herbal contraceptive development. Treatment with above fractions of Terminalia chebula showed a significant diminution in the activities of androgenic key enzymes (Δ5, 3β-HSD, 17β-HSD) and inhibition in serum testosterone level in compare to the control. Significant up regulation of testicular Bax gene and down regulation of Bcl-2 gene indicated the hypotesticular activity of these fractions. Flow-cytometric study focused a significant diminution in sperm viability and sperm mitochondrial status after the treatment with different fractions. Out of these, ethyl acetate fraction showed most promising hypotesticular effect without impairing any toxicity in general which highlighted that the fraction may contains antitesticular agent(s) in threshold levels compare to other fractions as it decreases spermiological, testicular genomic sensors and elevates sperm apoptotic sensors that may lead to male contraception.
- MeSH
- látky blokující spermatogenezi * chemie izolace a purifikace MeSH
- modely u zvířat MeSH
- potkani Wistar MeSH
- průtoková cytometrie MeSH
- rostlinné extrakty MeSH
- spermie účinky léků MeSH
- Terminalia chemie MeSH
- testis enzymologie chemie účinky léků MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
Rostlinné látky ovlivňují zvýšené sérové hladiny cholesterolu různými mechanizmy, omezují vstřebávání cholesterolu a žlučových kyselin ve střevě, inhibují syntézu cholesterolu v játrech, chrání LDL-cholesterol před oxidací a zvyšují obsah HDL-cholesterolu na úkor LDL-cholesterolu.
Plant substances affect elevated serum cholesterol levels by a variety of mechanisms: they reduce intestinal cholesterol and bile acid absorption, inhibit hepatic cholesterol synthesis, protect LDL-cholesterol from oxidation, and increase HDL-cholesterol content at the expense of LDL-cholesterol.
- MeSH
- Allium MeSH
- čajovník čínský MeSH
- Chlorella MeSH
- cholesterol biosyntéza krev škodlivé účinky MeSH
- Chondrus MeSH
- Cyamopsis MeSH
- Cynara scolymus MeSH
- Fabaceae MeSH
- Ganoderma MeSH
- Glycine max MeSH
- Gymnema sylvestre MeSH
- Hippophae MeSH
- kukuřice setá MeSH
- kustovnice MeSH
- len MeSH
- Lentinula MeSH
- lidé MeSH
- Medicago sativa MeSH
- Olea MeSH
- perila křovitá MeSH
- Persea MeSH
- Phyllanthus emblica MeSH
- Plantago MeSH
- Pleurotus MeSH
- pšenice MeSH
- Quillaja MeSH
- rýže (rod) MeSH
- Saccharomyces MeSH
- šišák bajkalský MeSH
- Sophora MeSH
- Spirulina MeSH
- Terminalia MeSH
- Trifolium MeSH
- Vaccinium myrtillus MeSH
- Vitis MeSH
- zázvor lékařský MeSH
- ženšen MeSH
- Check Tag
- lidé MeSH
This study was designed to evaluate the effect of Terminalia chebula fruit extract on the levels of plasma and tissue glycoprotein components in streptozotocin-induced-diabetic rats. Oral administration of T. chebula fruit extract at a concentration of 200 mg/kg body weight for 30 days significantly reduced the levels of blood glucose, glycosylated hemoglobin, urea, and creatinine as well as fucose, hexose, hexosamine and sialic acid in the diabetic rats treated with the fruit extract. The observed decrease in the levels of plasma insulin and C-peptide in the diabetic rats was elevated to near normal by T. chebula fruit extract treatment. Histological observations made on the pancreatic tissue of control and experimental groups also revealed the beneficial effect of T. chebula fruit extract. The efficacy of the fruit extract was comparable with glibenclamide, a known hypoglycaemic drug.
- MeSH
- ájurvéda MeSH
- C-peptid diagnostické užití krev MeSH
- experimentální diabetes mellitus komplikace metabolismus MeSH
- glibenklamid metabolismus MeSH
- glykoproteiny metabolismus škodlivé účinky MeSH
- inzulin izolace a purifikace krev metabolismus MeSH
- potkani Wistar MeSH
- streptozocin metabolismus škodlivé účinky MeSH
- Terminalia metabolismus MeSH
- MeSH
- infarkt myokardu diagnóza patologie prevence a kontrola MeSH
- ischemické přivykání metody MeSH
- isoprenalin farmakologie MeSH
- krysa rodu rattus MeSH
- léčivé rostliny fyziologie MeSH
- lyzozomy enzymologie fyziologie účinky léků MeSH
- modely nemocí na zvířatech MeSH
- rostlinné extrakty terapeutické užití MeSH
- Terminalia MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
