Steroidal glycoalkaloids present in Solanaceae are toxic compounds biosynthesised for the protection of the plants. However, many health benefits of these compounds have been reported so far. One of their promising targets might be cancer, as demonstrated in a large number of studies. However, the main mechanism of action seems to be unclear. It could include the induction of apoptosis or trigger a necrosis with a subsequent inflammatory response. The relatively high systemic toxicity of steroidal compounds is another effect that must be taken into account in anticancer research. The main aim of this work was to summarise the recent progress in the investigation of the mechanisms of their antitumour action and to discuss their potential.
- MeSH
- alkaloidy Solanaceí izolace a purifikace farmakologie toxicita MeSH
- antitumorózní látky fytogenní izolace a purifikace farmakologie toxicita MeSH
- lidé MeSH
- rostlinné extrakty izolace a purifikace farmakologie toxicita MeSH
- Solanaceae chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- alkaloidy Solanaceí klasifikace toxicita MeSH
- atropin farmakologie chemie MeSH
- čarodějnictví dějiny MeSH
- dospělí MeSH
- halucinogeny škodlivé účinky MeSH
- Hyoscyamus MeSH
- lidé MeSH
- rostlinné extrakty MeSH
- rostliny MeSH
- skopolamin farmakologie chemie MeSH
- Solanaceae účinky léků MeSH
- solanin toxicita MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
