Potatoes are a source of glycoalkaloids (GAs) represented primarily by alpha-solanine and alpha-chaconine (about 95%). Content of GAs in tubers is usually 10-100 mg/kg and maximum levels do not exceed 200 mg/kg. GAs can be hazardous for human health. Poisoning involve gastrointestinal ailments and neurological symptoms. A single intake of >1-3 mg/kg b.w. is considered a critical effect dose (CED). Probabilistic modelling of acute and chronic (usual) exposure to GAs was performed in the Czech Republic, Sweden and The Netherlands. National databases on individual consumption of foods, data on concentration of GAs in tubers (439 Czech and Swedish results) and processing factors were used for modelling. Results concluded that potatoes currently available at the European market may lead to acute intakes >1 mg GAs/kg b.w./day for upper tail of the intake distribution (0.01% of population) in all three countries. 50 mg GAs/kg raw unpeeled tubers ensures that at least 99.99% of the population does not exceed the CED. Estimated chronic (usual) intake in participating countries was 0.25, 0.29 and 0.56 mg/kg b.w./day (97.5% upper confidence limit). It remains unclear if the incidence of GAs poisoning is underreported or if assumptions are the worst case for extremely sensitive persons.
- MeSH
- lidé MeSH
- přijímání potravy MeSH
- solanin analogy a deriváty analýza MeSH
- Solanum tuberosum chemie MeSH
- statistické modely MeSH
- vystavení vlivu životního prostředí analýza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
- MeSH
- alkaloidy Solanaceí klasifikace toxicita MeSH
- atropin farmakologie chemie MeSH
- čarodějnictví dějiny MeSH
- dospělí MeSH
- halucinogeny škodlivé účinky MeSH
- Hyoscyamus MeSH
- lidé MeSH
- rostlinné extrakty MeSH
- rostliny MeSH
- skopolamin farmakologie chemie MeSH
- Solanaceae účinky léků MeSH
- solanin toxicita MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- dítě MeSH
- lidé MeSH
- nemoci přenášené potravou mortalita MeSH
- solanin MeSH
- Solanum tuberosum MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
