OBJECTIVE: To assess the gender differences in correlation lipoprotein(a) concentration with the extent of coronary artery disease in patients with established coronary artery disease. PATIENTS AND METHODS: Blood lipids and lipoprotein(a) concentrations were measured in 351 consecutive patients (256 men and 95 women) who underwent coronary angiography between January and May 2010, and who had established coronary atherosclerosis (angiography score >1). A modified angiographic Gensini Score was used. RESULTS: Mean angiographic score was 19.6 in men and 15.0 in women. Men had lower mean high-density lipoprotein cholesterol level than women (1.05 vs. 1.18 mmol/l) and lower mean apolipoprotein A level (1.41 vs. 1.53 g/l). Mean lipoprotein(a) level was higher in men than women (307.1 vs. 282.7 mg/l). Significant inverse correlation between high-density lipoprotein cholesterol and apoA with angiographic score was identified in women (r = -0.23, p = 0.028 and r = -0.26, p = 0.025), but not in men. Lipoprotein(a) level correlated significantly with angiographic score only in men (r = 0.168, p = 0.0185). CONCLUSIONS: Gender differences were identified in patients with established coronary atherosclerosis in the relation of blood lipids and lipoprotein(a) levels with the extent of coronary artery disease.

• MeSH
• apoprotein(a) krev   MeSH
• cholesterol krev   MeSH
• koronární angiografie MeSH
• koronární cévy radiografie   MeSH
• lidé MeSH
• lipoprotein (a) krev   MeSH
• lipoproteiny krev   MeSH
• nemoci koronárních tepen krev   radiografie   MeSH
• sexuální faktory MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Lipoprotein(a) [Lp(a)] comprises of an LDL particle and apolipoprotein(a) [apo(a)] and its elevated levels are considered a risk factor for atherosclerosis. The aim of our study was to find out whether elevated Lp(a) levels are associated with increased risk of atherosclerosis in patients with multiple other risk factors. We further tested the association of three polymorphisms of the apo(a) gene promoter with Lp(a) levels. No significant correlation was detected between Lp(a) levels and lipid and clinical parameters tested. The study demonstrated a significantly (p=0.0219) elevated Lp(a) level (mean 28±35 mg/dl, median 0.14) in patients with coronary heart disease (CHD). In a group with premature CHD the correlation was not significant anymore. There was a significant correlation between polymorphic loci of the promoter region of apo(a) gene and Lp(a) levels (+93C>T, p=0.0166, STR, p<0.0001). Our study suggests that elevated Lp(a) level is an independent risk factor of CHD in carriers of other important CHD risk factors. Observed association of sequence variants of the promoter of apo(a) gene with Lp(a) levels is caused in part due to linkage to a restricted range of apo(a) gene length isoforms.

• Klíčová slova
• Lipoprotein(a), Apolipoprotein(a), Atherosclerosis, Risk factors, Coronary heart disease, Gene polymorphisms,
• MeSH
• apoprotein(a) genetika   krev   MeSH
• biologické markery krev   MeSH
• diabetes mellitus 2. typu MeSH
• dospělí MeSH
• financování organizované MeSH
• hodnocení rizik MeSH
• hypertenze komplikace   MeSH
• koronární nemoc etiologie   genetika   metabolismus   MeSH
• kouření škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lipidy krev   MeSH
• lipoprotein (a) genetika   krev   MeSH
• nadváha komplikace   MeSH
• nemoci koronárních tepen etiologie   genetika   metabolismus   MeSH
• polymorfismus genetický MeSH
• promotorové oblasti (genetika) MeSH
• rizikové faktory MeSH
• senioři MeSH
• upregulace MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH