The purpose of the study was to assess whether the occurrence of restenosis is associated with CD45+ platelet count and neutrophil to lymphocyte ratio in patients with type 2 diabetes mellitus (DM) after drug-eluting stent (DES) implantation for stable coronary artery disease (CAD). The study comprised 126 patients, including 55 patients with type 2 DM and stable CAD who underwent elective coronary artery stenting with DES and follow-up angiography within 6 to 12 months. Blood samples were collected from each patient on the morning of the coronary angiography procedure. The variables related to in-stent restenosis were selected by logistic regression analysis. The logistic regression analysis showed that 2 inflammatory factors, CD45+ platelet count (odds ratio [OR] = 4.51, 95% confidence interval [CI]: 1.50-13.50, P = .007) and neutrophil to lymphocyte ratio (OR = 3.09, 95% CI: 1.05-9.10, P = .04), were significantly associated with the risk of in-stent restenosis after stenting with DES in patients with stable CAD and type 2 DM. A receiver operator characteristic curve analysis indicated that the area under the curve was 0.83% (0.05%; P < .001), which showed that the logistic model had good predictive accuracy (based on CD45+ platelet count and neutrophil to lymphocyte ratio) for the risk of in-stent restenosis development in DES in patients with CAD and type 2 DM. Two novel biomarkers of restenosis, CD45+ platelet count and neutrophil to lymphocyte ratio, may be effectively used to predict in-stent restenosis after DES implantation in patients with CAD and type 2 DM.
- MeSH
- antigeny CD45 krev MeSH
- biologické markery krev MeSH
- diabetes mellitus 2. typu krev patologie chirurgie MeSH
- diabetické angiopatie krev patologie chirurgie MeSH
- koronární restenóza krev patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen krev patologie chirurgie MeSH
- počet trombocytů MeSH
- senioři MeSH
- stenty uvolňující léky * MeSH
- trombocyty metabolismus patologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
Takayasu arteritis (TA) is an inflammatory disease affecting large and medium-sized arteries and causing occlusive, aneurysmal, or stenotic lesions. It is also known that with chronic course, the disease has a tendency to recur at either the same site or different. We report a patient with TA whose carotid stenosis was initially treated with bare metal stents but the patient suffered from recurring localized restenosis. Eventually, the patient was treated with (off-label) coronary drug-eluting stent and drug-eluting balloon with favorable long-term outcome. Therefore, we suggest that drug-eluting interventions might have a place in treatment of TA patients with recurring restenosis.
- MeSH
- balónková koronární angioplastika MeSH
- koronární restenóza etiologie patologie terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- recidiva MeSH
- stenty uvolňující léky * MeSH
- Takayasuova arteriitida komplikace terapie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- MeSH
- dospělí MeSH
- infarkt myokardu patologie terapie MeSH
- koronární angiografie MeSH
- koronární restenóza diagnóza patologie MeSH
- koronární stenóza patologie terapie MeSH
- lidé MeSH
- peroperační komplikace patologie terapie MeSH
- revaskularizace myokardu MeSH
- stenty MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
