• MeSH
• antigeny nádorové MeSH
• dospělí MeSH
• lidé MeSH
• melanom patologie   MeSH
• metastázy nádorů MeSH
• nádorové biomarkery MeSH
• nádory žaludku etiologie   patologie   MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• kazuistiky MeSH

Concurrent medullary and papillary carcinomas of the thyroid gland are rare and occurrence of the medullary and medullary-papillary carcinoma, as far as we know, has not been previously described. The medullary carcinoma was found in the upper part of the right lobe and the mixed medullary-papillary carcinoma in the left lobe of thyroid gland. Immunohistochemistry revealed calcitonin positivity in the medullary parts of the carcinoma and thyroglobulin positivity in papillary structures. Both light microscopy and immunohistochemistry observation distinguished these two cell lineages. The patient was treated with radiotherapy but died 18 months after first symptoms. Metastases were identified in the liver, mediastinal lymph nodes and soft tissues and micro-metastases in the lungs. The authors discuss histogenesis of mixed thyroid carcinomas.

• MeSH
• chromograniny analýza   MeSH
• kalcitonin analýza   MeSH
• keratiny analýza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• medulární karcinom patologie   MeSH
• mnohočetné primární nádory patologie   MeSH
• mucin 1 analýza   MeSH
• nádorové biomarkery analýza   MeSH
• nádorové proteiny analýza   MeSH
• nádory štítné žlázy patologie   MeSH
• thyreoglobulin analýza   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

Tumour of the rectum was found in 50-year old man. Two different components were identified. The rectal wall was infiltrated by a tumour with rhabdoid phenotype which formed majority of tumour mass. This type of tumour grew under differentiated tubular and mucinous adenocarcinoma which was present in small extent. Ultrastructurally rhabdoid cells revealed clusters and whorls of intermediate filaments without myoblastic differentiation. Strong anti-vimentin positivity prevailed over the anti-cytokeratin positivity. The authors suggest that this is a case of an adenocarcinoma transforming into a poorly differentiated form with rhabdoid phenotype.

• MeSH
• adenokarcinom * patologie   terapie   MeSH
• fenotyp MeSH
• invazivní růst nádoru MeSH
• kombinovaná terapie MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfatické metastázy MeSH
• mnohočetné primární nádory * patologie   terapie   terapie   MeSH
• mucinózní adenokarcinom * patologie   terapie   MeSH
• nádory rekta * patologie   terapie   MeSH
• progrese nemoci MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH