EEG power spectra Dotaz Zobrazit nápovědu
- MeSH
- duševní procesy MeSH
- elektroencefalografie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- MeSH
- elektroencefalografie metody MeSH
- lidé MeSH
- zraková percepce MeSH
- Check Tag
- lidé MeSH
There is now an overwhelming preponderance of evidence that cognitive behavioural therapy for insomnia (CBT-I) is effective, as effective as sedative hypnotics during acute treatment (4-8 weeks), and is more effective in long term (following treatment). Although the efficacy of CBT-I in the treatment of chronic insomnia is well known, however there is little objective data on the effects of CBT-I on sleep architecture and sleep EEG power densities. The present study evaluated, first, subjective change in sleep quality and quantity, and secondly the modifications occurring in polysomnography and EEG power densities during sleep after 8 weeks of CBT-I. Nine free drug patients with psychophysiological insomnia, aged 33-62 years (mean age 47 +/- 9.7 years), seven female and two male participated in the study. Self-report questionnaires were administered 1 week before and 1 week after CBT-I, a sleep diary was completed each day 1 week before CBT-I, during CBT-I and 1 week after CBT-I. Subjects underwent two consecutive polysomnographic nights before and after CBT-I. Spectral analysis was performed the second night following 16 h of controlled wakefulness. After CBT-I, only scales assessing insomnia were significantly decreased, stages 2, REM sleep and SWS durations were significantly increased. Slow wave activity (SWA) was increased and the SWA decay shortened, beta and sigma activity were reduced. In conclusion CBT-I improves both subjective and objective sleep quality of sleep. CBT-I may enhance sleep pressure and improve homeostatic sleep regulation.
- MeSH
- bdění fyziologie MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- homeostáza MeSH
- kognitivně behaviorální terapie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- polysomnografie přístrojové vybavení MeSH
- poruchy iniciace a udržování spánku diagnóza terapie MeSH
- průzkumy a dotazníky MeSH
- spánek fyziologie MeSH
- stadia spánku fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
In the present study we investigated the potential antipsychotic effects of the mGlu2/3 agonist LY379268 on changes in EEG power spectra and coherence in the ketamine model of psychosis. In order to use behaviorally active drug doses, experiments detecting changes in locomotor activity and sensorimotor gating were also conducted. In EEG experiments, adult male Wistar rats were injected with ketamine 30 mg/kg i.p. and LY379268 3 mg/kg i.p. Cortical EEG was recorded from twelve (2 × 6) electrodes placed homolaterally on each hemisphere. To avoid interference with the behavioral hyperactivity of ketamine challenge, the behavioral activity of animals was simultaneously registered at the time of recording. Subsequent power spectral and coherence analyses were assessed in epochs corresponding to behavioral inactivity. Analysis of segments with behavioral activity compared to inactivity was also performed. The effects of LY379268 3 mg/kg i.p. on the deficits in sensorimotor processing and on hyperlocomotion induced by ketamine were evaluated in the test of prepulse inhibition of acoustic startle reaction (PPI ASR) and in the open field. LY379268 reversed the ketamine-induced hyperlocomotion but had no effect on ketamine-induced PPI deficits. In EEG epochs corresponding to behavioral inactivity ketamine decreased the power in the delta band, induced a power increase in the high frequency bands and globally decreased EEG coherence. Pretreatment with the LY379268 completely reversed the ketamine-induced power increase in high frequency bands and had a partial effect on EEG coherence. LY379268 alone induced a decrease of beta, high beta and low-gamma power, and an increase in coherence in high frequency bands. Additional analysis revealed that behavioral activity increases power as well as coherence in most frequency bands. In conclusion, agonism of mGlu2/3 receptors was effective in reversing most of the changes induced by ketamine, however due to the lack of effectiveness on PPI deficits its potential antipsychotic properties remain disputable.
- MeSH
- aminokyseliny farmakologie terapeutické užití MeSH
- antipsychotika farmakologie terapeutické užití MeSH
- bicyklické sloučeniny heterocyklické farmakologie terapeutické užití MeSH
- elektroencefalografie účinky léků metody MeSH
- ketamin toxicita MeSH
- krysa rodu rattus MeSH
- modely nemocí na zvířatech * MeSH
- potkani Wistar MeSH
- psychotické poruchy farmakoterapie patofyziologie MeSH
- receptory metabotropního glutamátu agonisté MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Pro schizofrenii jsou charakteristické změny jak v kvantitativním EEG, tak i významný deficit v senzorimotorickém zpracování. Cílem této práce bylo srovnat vliv tryptaminového (psilocin) a fenyletylaminového (mezkalin) halucinogenu v animálním modelu psychózy. Testovali jsme senzomotorické zpracování informací a vliv na funkční konektivitu mozku pomocí kvantitativního EEG (qEEG). EEG záznam jsme registro¬ vali ze 12 subdurálních elektrod umístěných nad homologními částmi frontální, motorické, parietální a temporální mozkové kůry u volně se pohybujících potkanů. Obě látky narušily senzorimotorické zpracování informací a z hlediska qEEG indukovaly deficit ve funkční konektivitě. Tento deficit se projevoval jak snížením EEG výkonu napříč spektrem, a tak i snížením EEG koherencí. Naše data vykazují značnou podobnost s nálezy u nemocných schizofrenií, což vypovídá o validitě použitých modelů.
Deficits in senzorimotor information processing as well as some changes in quantitative EEG (qEEG) are characteristic for schiz ophrenia. This study focuses on a comparision of two hallucinogens, tryptamine (psilocin) and phenylethylamine (meskaline), in an animal model of psychosis. The registration of qEEG was performed from 12 subdural electrodes placed on six homologous sites of frontal, motor, parietal and temporal cortex in freely moving rats. Both substances disrupted senzorimotor information processing as well as they both decre ased functio- nal connectivity in qEEG (i.e. decrease in power spectra and coherence). Our data are similar to findings of schizophrenia pati ents, confirming validity of used models.
- Klíčová slova
- prepulzní inhibice úlekové reakce, EEG koherence, EEG spektra, potkan,
- MeSH
- elektroencefalografie statistika a číselné údaje účinky léků MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- krysa rodu rattus MeSH
- lokomoce účinky léků MeSH
- meskalin aplikace a dávkování MeSH
- modely nemocí na zvířatech MeSH
- mozek patofyziologie účinky léků MeSH
- potkani Wistar MeSH
- psilocybin analogy a deriváty aplikace a dávkování MeSH
- schizofrenie patofyziologie MeSH
- sluchová percepce fyziologie účinky léků MeSH
- úleková reakce účinky léků MeSH
- výzkum statistika a číselné údaje MeSH
- výzkumný projekt MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
