Since the first description of sinonasal undifferentiated carcinoma (SNUC) as a distinctive highly aggressive sinonasal neoplasm with probable origin from the sinonasal mucosa (Schneiderian epithelium), SNUC has been the subject of ongoing study and controversy. In particular, the SNUC category gradually became a "wastebasket" for any undifferentiated or unclassifiable sinonasal malignancy of definite or probable epithelial origin. However, with the availability of more specific and sensitive immunohistochemical antibodies and increasing implementation of novel genetic tools, the historical SNUC category became the subject of progressive subdivision leading to recognition of specific genetically defined, reproducible subtypes. These recently recognized entities are characterized by distinctive genetic aberrations including NUTM1-rearranged carcinoma (NUT carcinoma) and carcinomas associated with inactivation of different members of the SWI/SNF chromatin-remodeling gene complex such as SMARCB1-deficient and less frequently SMARCA4-deficient carcinoma. The ring became almost closed, with recent studies highlighting frequent oncogenic IDH2 mutations in the vast majority of histologically defined SNUCs, with a frequency of 82%. A review of these cases suggests the possibility that "true SNUC" probably represents a distinctive neoplastic disease entity, morphologically, phenotypically, and genetically. This review addresses this topic from a historical perspective, with a focus on recently recognized genetically defined subsets within the SNUC spectrum.
- MeSH
- DNA Helicases genetics MeSH
- SMARCB1 Protein genetics MeSH
- Nuclear Proteins genetics MeSH
- Carcinoma diagnosis epidemiology genetics MeSH
- Humans MeSH
- Biomarkers, Tumor genetics MeSH
- Maxillary Sinus Neoplasms diagnosis epidemiology genetics MeSH
- Transcription Factors genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The International Collaboration on Cancer Reporting is a nonprofit organization whose goal is to develop evidence-based, internationally agreed-upon standardized data sets for each anatomic site, to be used throughout the world. Providing global standardization of pathology tumor classification, staging, and other reporting elements will lead to achieving the objective of improved patient management and enhanced epidemiologic research. Salivary gland carcinomas are relatively uncommon, and as such, meaningful data about the many histologic types are not easily compared. Morphologic overlap between tumor types makes accurate classification challenging, but there are often significant differences in patient outcomes. Therefore, issues related to tumor type, tumor grading, high-grade transformation, extent of invasion, number and size of nerves affected, and types of ancillary studies are discussed in the context of daily application to specimens from these organs. This review focuses on the data set developed for salivary gland carcinomas with discussion of the key core and noncore elements developed for inclusion by an international expert panel of head and neck and oral-maxillofacial pathologists and surgeons.
Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.
- MeSH
- Carcinoma, Acinar Cell * epidemiology metabolism pathology therapy MeSH
- Diagnosis, Differential MeSH
- Microscopy, Electron MeSH
- Humans MeSH
- Salivary Glands, Minor MeSH
- Disease Models, Animal MeSH
- Salivary Gland Neoplasms epidemiology metabolism pathology therapy MeSH
- Parotid Gland MeSH
- Preoperative Care MeSH
- Prognosis MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis of head and neck AdCC is variable, and ranges between 3% and 16%. Metastasis to the cervical lymph nodes of intraoral and oropharyngeal AdCC varies from 2% to 43%, with the lower rates pertaining to palatal AdCC and the higher rates to base of the tongue. Neck node recurrence may happen after treatment in 0-14% of AdCC, is highly dependent on the extent of the treatment and is very rare in patients who have been treated with therapeutic or elective neck dissections, or elective neck irradiation. Lymph node involvement with or without extracapsular extension in AdCC has been shown in most reports to be independently associated with decreased overall and cause-specific survival, probably because lymph node involvement is a risk factor for subsequent distant metastasis. The overall rate of occult neck metastasis in patients with head and neck AdCC ranges from 15% to 44%, but occult neck metastasis from oral cavity and/or oropharynx seems to occur more frequently than from other locations, such as the sinonasal tract and major salivary glands. Nevertheless, the benefit of elective neck dissection (END) in AdCC is not comparable to that of squamous cell carcinoma, because the main cause of failure is not related to neck or local recurrence, but rather, to distant failure. Therefore, END should be considered in patients with a cN0 neck with AdCC in some high risk oral and oropharyngeal locations when postoperative RT is not planned, or the rare AdCC-high grade transformation.
- MeSH
- Carcinoma, Adenoid Cystic pathology therapy MeSH
- Neck Dissection * MeSH
- Neck MeSH
- Humans MeSH
- Neoplasm Recurrence, Local * MeSH
- Lymphatic Metastasis MeSH
- Lymph Nodes pathology MeSH
- Disease Management MeSH
- Oropharyngeal Neoplasms pathology therapy MeSH
- Mouth Neoplasms pathology therapy MeSH
- Radiotherapy * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991-2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.
- MeSH
- Carcinoma, Adenoid Cystic * pathology surgery MeSH
- Elective Surgical Procedures methods MeSH
- Neck Dissection methods MeSH
- Humans MeSH
- Lymphatic Metastasis MeSH
- Lymph Nodes * pathology surgery MeSH
- Laryngeal Neoplasms * pathology surgery MeSH
- Patient Selection MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
- MeSH
- Carcinoma, Adenoid Cystic mortality pathology surgery MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Lymphatic Metastasis pathology MeSH
- Lymph Nodes pathology MeSH
- Salivary Gland Neoplasms mortality pathology surgery MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Sclerosing polycystic adenosis (SPA) is a recently described, rare lesion of the salivary glands that bears a resemblance to epithelial proliferative lesions of the breast. The true nature of the lesion is unknown, but up to now it has been generally believed to represent a pseudoneoplastic sclerosing and inflammatory process. However, local recurrence developed in about one-third of the cases. Superimposed dysplastic changes ranging from low-grade dysplasia to carcinoma in situ were described in SPA. Although no metastases-related and/or disease-related patient deaths were documented, these clinical and histopathologic features raise the possibility that SPA might represent a neoplastic lesion. Polymorphism of the human androgen receptor locus is most frequently used to assess whether the pattern of X-chromosome inactivation is random or nonrandom, the latter strongly indicating clonality. In this study, the assay was applied to tissue from 12 examples of SPA. Three cases (males) were noninformative and 3 cases (females) could not be analyzed owing to poor quality of DNA, but all the remaining 6 lesions satisfied the criteria for monoclonality. We therefore conclude that the findings in the present study are further supporting evidence that SPA is a neoplasm, and not just a reactive process.
- MeSH
- Receptors, Androgen genetics MeSH
- Clone Cells MeSH
- Child MeSH
- Adult MeSH
- X Chromosome Inactivation MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor analysis MeSH
- Salivary Gland Neoplasms genetics pathology MeSH
- Polymerase Chain Reaction MeSH
- Polymorphism, Genetic MeSH
- Aged MeSH
- Sclerosis MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
World Health Organization classification of tumours
430 s. : il.
1st ed. 430 s. : il. (některé barev.) ; 27 cm
Pathology and Genetics of Head and Neck Tumours is the latest volume in the new WHO series, on histological and genetic typing of human tumours. This authoritative, concise reference book, provides an international standard for pathologists and oncologists and will serve as an indispensable, guide for use in the design of studies monitoring response to therapy and clinical outcome., Diagnostic criteria, pathological features, and associated genetic alterations are described in a, strictly disease-oriented manner. Sections on all WHO-recognized neoplasms and their variants include new ICD-O codes, incidence, age and sex distribution, location, clinical signs and symptoms, pathology, genetics, and predictive factors. The book, prepared by 130 authors from 28 countries, contains 890 color photographs, X-rays, computed tomography (CT), magnetic resonance (MR) images, charts, and more than 2900 references. This volume covers tumours of the nasal cavity and paranasal sinuses, of the nasopharynx, of the hypophyranyx, larynx and trachea, of the oral cavity and oropharynx, of salivary glands, as well as odontogenetic tumours, tumours of the ear, the paraganglionic system, and inherited tumour syndromes. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases.This book is in the series commonly referred to as the \"Blue Book\" series.Pathology and Genetics of Head and Neck TumorsContributors::Dr. Susan L. Abbondanz, Dr. Lucía Alós Dr. Mario Altini, Dr. Paul L. Auclair Dr. Gisle Bang, Dr. Leon Barnes, Dr. Timothy J. Beale, Dr. Franco Bertoni, Dr. Wojciech Biernat, Dr. Paolo Boffetta, Dr. Jerry E. Bouquot, Dr. Margaret S. Brandweingensler, Dr. Robert B. Brannon, Dr. Freddie Bray, Dr. John J. Buchino, Dr. Amos Buchner, Dr. Joseph Califano, Dr. Eduardo Calonje, Dr. Antonio Cardesa, Dr. Roman Carlos, Dr. John K.C. Chan, Dr. Alexander Chak-Lam Chan, Dr. Wah Cheuk, Dr. Michael M.C. Cheung, Dr. Hedley G. Coleman, Dr. Hugh D. Curtin, Dr. Gustave L. Davis, Dr. Vera Cavalcanti De Araujo, Dr. Louis P. Dehner, Dr. Pavel Dulguerov, Dr. Samir K. El Mofty, Dr. Adel K. El-Naggar, Dr. Gary Ellis, Dr. Cosme Ereodr. Lewis Roy Eversole, Dr. John W. Eveson, Dr. Julie C. Fanburg-Smith, Dr. Jacques Ferlay, Dr. Jorge A. Ferreiro, Dr. Isabel Fonseca, Dr. William Foo, Dr. Silvia Franceschi, Dr. Alessandro Franchi, Dr. Henry F. Frierson, Jr, Dr. Nina Galedr Yan Gao, Dr. David G. Gardner, Dr. Douglas R. Gnepp, Dr. Robert K. Goode, Dr. Kristiina Heikinheimo, Dr. Kristin Henry, Dr. Dolly P. Huang, Dr. Jennifer L. Hunt, Dr. Andrew G. Huvos, Dr. K. Thorsten Jäkel, Dr. Wei-Hua Jia, Dr. Newell W. Johnson, Dr. Gernot Jundt, Dr. Silloo B. Kapadia, Dr. Paul Kleihues, Dr. Sakari Knuutila, Dr. Hanna Strømme Koppang, Dr. Tseng-Tong Ku, Dr. Kimihide Kusafuka, Dr. Janez Lamovec, Dr. Constantino Ledesma-Montes, Dr. Anne W.M. Lee, Dr. Jean E. Lewis, Dr. T.J. Li, Dr. Kwok- Wai Lo, Dr. Thomas Loning, Dr. Yong Lu, Dr. Mario A. Luna, Dr. D. Gordon Macdonald, Dr. Peter Mccarron, Dr. Leslie Michaels, Dr. Michal Michal, Dr. Adalberto Mosqueda-Taylor, Dr. Alfons Nadal, Dr. Toshitaka Nagao, Dr. Hiromasa Nikai, Dr. Edward W. Odell, Dr. Kerry D. Olsen, Dr. Bayardo Perez-Ordone, Dr. Hans Peter Philipsen, Dr. Adriano Piattelli, Dr. Ben Z. Pilch, Dr. Finn Praetorius, Dr. Manju L. Prasad, Dr. Kunnambath Ramadas, Dr. Peter A. Reichart, Dr. Kiyoshi Saito, Dr. Ann Sandison, Dr. Marco Santucci, Dr. Patricia A. Schachern, Dr. Stephan Schmid, Dr. James J. Sciubba, Dr. Ratnam K. Shanmugaratnam, Dr. Mervyn Shear, Dr. Masaki Shimono, Dr. Chong Huat Siar, Dr. David Sidransky, Dr. Roderick H.W. Simpson, Dr. Alena Skálová, Dr. Lee J. Slater, Dr. Pieter J. Slootweg, Dr. Jorge Soares, Dr. Leslie Sobin, Dr. Sava Soucek, Dr. Paul M. Speight, Dr. Göran Stenman, Dr. Kai Hua Sun, Dr. Takashi Takata, Dr. Yasunori Takeda, Dr. Lester D.R. Thompson, Dr. Charles E. Tomich, Dr. William Y.W. Tsang, Dr. Loretta L.Y. Tse, Dr. K. Krishnan Unni, Dr. Mark L. Urken, Dr. Isaac Van Der Waal, Dr. Jacqueline E. Van Der Wal, Dr. Bruce M. Wenig, Dr. William H. Westra, Dr. Timothy Tak-Chun Yip, Dr. Yi- Xin Zeng, Dr. Nina Zidar
... D. Wilson, J. L. Atkins, D. R. Bell, 3. E. Stork, V. L. Cook, A. H. Reese, F. D. Reese, K. ... ... Wolfe, D. L. Rutt, J. B. ... ... Biggi, D. Giordano, G. R. Ciŕo, A. ... ... Lombardi, R. Bianco, G. Cozzi, D. Mere-gaglia, R. ... ... Regazzoni, D. Meregaglia, R. Bianco, L. ...
424 s. : il.
