- MeSH
- Ethinyl Estradiol pharmacology MeSH
- Humans MeSH
- Ovulation drug effects MeSH
- Pregnanediol metabolism MeSH
- Check Tag
- Humans MeSH
- Female MeSH
Purpose: The contraceptive pill is an effective and safe method of preventing pregnancy. The progestins used for contraception either are components of a combined hormonal contraceptive (tablets, patches or vaginal rings) or are used alone in progestin-only formulations. Progestin-only contraceptives are available as daily oral preparations, subcutaneous or intramuscular injectables (every 1-3 months), subdermal implants (every 3-5 years) and intrauterine systems (every 3-5 years). Long-acting progestins are highly effective in typical use and have a very low risk profile and few contraindications.Material and Methods: A new progestin-only, oestrogen-free contraceptive, drospirenone, in a dosage of 4 mg/day in a 24/4 regimen, has received regulatory approval in the USA and the EU. The molecule has antigonadotropic, antimineralocorticoid, antiestrogenic and antiandrogenic properties.Results: The regimen was chosen to improve the bleeding profile; maintain plasma oestradiol levels at those of the early follicular phase, to avoid hypoestrogenism; and preserve efficacy even with a missed pill, as drospirenone has a half-life of 30-34 h.Conclusions: Clinical studies have shown good efficacy, very low cardiovascular side effects and a favourable bleeding pattern, as well as maintenance of ovulation inhibition after scheduled 24 h delays in pill intake.
- MeSH
- Androstenes pharmacology MeSH
- Ovulation Inhibition drug effects MeSH
- Clinical Trials as Topic MeSH
- Contraceptives, Oral pharmacology MeSH
- Humans MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Keywords
- Cerazette,
- MeSH
- Cervix Mucus drug effects MeSH
- Desogestrel therapeutic use MeSH
- Ovulation Inhibition drug effects MeSH
- Contraceptives, Oral classification MeSH
- Check Tag
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- Dienogest,
- MeSH
- Drug Evaluation utilization MeSH
- Ovulation Inhibition drug effects MeSH
- Contraceptives, Oral, Hormonal pharmacokinetics pharmacology chemistry MeSH
- Humans MeSH
- Nandrolone administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Review MeSH
- Keywords
- Cerazette,
- MeSH
- Risk Assessment MeSH
- Ovulation Inhibition MeSH
- Contraceptives, Oral, Hormonal MeSH
- Humans MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Keywords
- Cerazette,
- MeSH
- Ovulation Inhibition MeSH
- Breast Feeding MeSH
- Contraceptives, Oral, Hormonal administration & dosage MeSH
- Levonorgestrel administration & dosage MeSH
- Humans MeSH
- Progesterone blood MeSH
- Menorrhagia MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Randomized Controlled Trial MeSH
European journal of contraception & reproductive health care, ISSN 1362-5187 Vol. 7, suppl. 2, December 2002
39 s. : il., tab. ; 30 cm
- MeSH
- Contraceptive Devices, Female MeSH
- Administration, Intravaginal MeSH
- Ethinyl Estradiol administration & dosage pharmacokinetics therapeutic use MeSH
- Drug Evaluation MeSH
- Ovulation Inhibition drug effects MeSH
- Hemorrhage MeSH
- Publication type
- Collected Work MeSH
- Conspectus
- Farmacie. Farmakologie
- NML Fields
- farmacie a farmakologie
- reprodukční lékařství
- MeSH
- Androgen Antagonists MeSH
- Mineralocorticoid Receptor Antagonists MeSH
- Ovulation Inhibition MeSH
- Clinical Trials as Topic MeSH
- Contraceptives, Oral, Hormonal MeSH
- Humans MeSH
- Progestins * administration & dosage pharmacology MeSH
- Renin-Angiotensin System drug effects MeSH
- Statistics as Topic MeSH
- Body Weight MeSH
- Check Tag
- Humans MeSH
- Female MeSH
