• Klíčová slova
• senioři, příručka,
• MeSH
• příroda MeSH
• zahradní terapie MeSH

• MeSH
• ateroskleróza MeSH
• dehydroepiandrosteron analogy a deriváty   krev   MeSH
• dospělí MeSH
• infarkt myokardu krev   MeSH
• inzulin krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• věkové skupiny MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

INTRODUCTION: Transverse-aortic constriction (TAC) operation is a widely used animal model to induce hypertrophy and heart failure through left-ventricular pressure overload. In mice, the cardiac response to TAC exhibits considerable variability influenced by factors such as strain, sub-strain, age, sex and vendor. METHODS: To investigate the impact of suture material (silk versus prolene) and size (6-0 versus 7-0) on the TAC-induced phenotype, we performed surgeries on male C57BL6/N mice at 9 weeks of age defining the aortic constriction by a 27G needle, thereby employing most frequently used methodological settings. The mice were randomly assigned into four separate groups, 6-0 silk, 7-0 silk, 6-0 prolene and 7-0 prolene (10 mice per group). Echocardiography was conducted before TAC and every 4 weeks thereafter to monitor the development of heart failure. Repeated measures correlation analysis was employed to compare disease progression among the different groups. RESULTS: Our findings reveal a significant influence of the chosen suture material on TAC outcomes. Mice operated with prolene showed increased mortality, slower body weight gain, faster left-ventricular mass increase, and a faster decline in left-ventricular ejection fraction, fractional shortening and aortic pressure gradient compared to silk-operated mice. Moreover, despite non significant, using thinner suture threads (7-0) tended to result in a more severe phenotype compared to thicker threads (6-0) across all tested parameters. DISCUSSION: Collectively, our results highlight the importance of suture material selection in determining the cardiac phenotype induced by TAC and emphasize the need to consider this factor when comparing data across different research laboratories.

• Publikační typ
• časopisecké články MeSH

• MeSH
• cholesterol analýza   krev   MeSH
• dehydroepiandrosteron analýza   krev   MeSH
• dehydroepiandrosteronsulfát analýza   krev   MeSH
• dospělí MeSH
• infarkt myokardu MeSH
• lidé MeSH
• rizikové faktory MeSH
• senioři MeSH
• triglyceridy analýza   krev   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

• MeSH
• časové faktory MeSH
• dospělí MeSH
• estradiol krev   metabolismus   MeSH
• finanční podpora výzkumu jako téma MeSH
• Glycine max metabolismus   MeSH
• kognice MeSH
• lidé MeSH
• potravní doplňky zásobování a distribuce   MeSH
• psychologické testy MeSH
• testosteron krev   metabolismus   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH

• MeSH
• chemoprofylaxe MeSH
• finanční podpora výzkumu jako téma MeSH
• jod aplikace a dávkování   MeSH
• lidé MeSH
• štítná žláza patofyziologie   patologie   MeSH
• uzle štítné žlázy diagnóza   epidemiologie   MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Slovenská republika MeSH

Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .

• MeSH
• dospělí MeSH
• emoce MeSH
• lidé MeSH
• mínění MeSH
• mladiství MeSH
• mladý dospělý MeSH
• psychologické modely MeSH
• sociální percepce etnologie   psychologie   MeSH
• srovnání kultur MeSH
• výraz obličeje MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH