• MeSH
• Epidemiologic Studies MeSH
• Risk Assessment statistics & numerical data   MeSH
• Carcinogens, Environmental MeSH
• Carcinogens MeSH
• Neoplasms epidemiology   MeSH
• Occupational Exposure MeSH
• Retrospective Studies MeSH
• Health Status Indicators MeSH
• Environmental Exposure MeSH
• Publication type
• News MeSH

• Conspectus
• Veřejné zdraví a hygiena
• NML Fields
• veřejné zdravotnictví
• environmentální vědy
• onkologie

• Publication type
• Meeting Abstract MeSH

• Publication type
• Meeting Abstract MeSH

The aim of this study is to analyze the genotoxic risks in the Moravian-Silesian Region in the Czech Republic and assess the significance of genotoxic factors in the etiology of cancer by bringing together the Registry of Occupational Exposure to Genotoxic Factors and the Cancer Registry and compare the rate of detected cancer in persons exposed to genotoxic factors via their work in the Moravian-Silesian Region with the occurrence of cancer in the population of the Czech Republic. The results show: (a) For the monitored group (748 person) for the period 1996-2008, according to gender, was no statistically significant difference in the incidence of oncological diseases compared to the population of the Czech Republic. (b) But statistically significant difference was found in the cases of oncological diseases in groups according to % AB.C. using the Cytogenetic analysis of human peripheral lymphocytes (CAPL). The highest incidence was in the group with a higher incidence of % AB.C. High values of % AB.C. may predict the development of oncological diseases.

• MeSH
• Incidence MeSH
• Humans MeSH
• Mutagens toxicity   MeSH
• Neoplasms chemically induced   epidemiology   MeSH
• Occupational Exposure * MeSH
• Registries MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Czech Republic MeSH

Cílem práce byl popis a analýza údajů evidovaných v registru profesionálních expozic genotoxickým faktorům v rámci Moravskoslezského kraje (MSK). Bylo vybráno 748 osob, jež byly v registru minimálně od roku 2005 a byly v evidenci alespoň tři roky, převážně v expozici genotoxickým faktorům chemického charakteru. Průměrná délka expozice byla 15,1 let. Ze 748 osob byla cytogenetická analýza lidských periferních lymfocytů provedena u 492 osob. Ve skupině zvýšené a vysoké expozice genotoxickým látkám bylo 341 osob. Tyto výsledky ukazují na zvýšenou expozici genotoxickým látkám a mohou tím zvyšovat pravděpodobnost rizika vzniku nádorových onemocnění. Osoby, které měly opakovaně zvýšené hodnoty procenta aberantních buněk, byly následně vyřazeny z expozice, a mnohdy i z evidence. Z evidence byly vyřazeny také osoby, které zemřely, nebo byl pracovní poměr ukončen. Tím dochází k přerušení pravidelných kontrol v době, kdy je největší předpoklad projevu biologického účinku dlouhodobé expozice genotoxickým látkám z důvodu latence a dochází tím i k přerušení poskytování cílené preventivní péče.

The objective of the work was to describe and analyze data kept in the files of the registry of occupational exposure to genotoxic factors within the Moravia-Silesia region. We selected 748 persons whose data were kept in the registry since 2005 for at least three years, mostly in the exposure to genotoxic factors of chemical nature. The mean duration of exposure was 15.1 years. Cytogenetic analysis of human peripheral lymphocytes was performed 492 subjects out of the 748 individuals. The group of increased and high exposure to genotoxic factors included 341 persons. The results indicate an increase exposure to genotoxic factors and thereby increased probability in development of tumor diseases. The persons whose values of percentage of aberrant cells had been repeatedly elevated were subsequently laid off the exposure and often also excluded from the register. Moreover, persons who died or were laid off the job were also excluded from the register. In this way, regular follow up was disrupted at the time, when there is the highest possibility that the biological effect of long-term exposure to genotoxic substances becomes manifest due to latency period the provision of preventive care was also disrupted.

• Keywords
• genotoxické riziko, cytogenetická analýza lidských periferních lymfocytů, registr, REGEX,
• MeSH
• Chromosome Aberrations chemically induced   statistics & numerical data   MeSH
• Risk Assessment methods   MeSH
• Carcinogens * classification   toxicity   MeSH
• Humans MeSH
• Lymphocytes cytology   MeSH
• Mutagens adverse effects   toxicity   MeSH
• Neoplasms genetics   chemically induced   prevention & control   MeSH
• Occupational Diseases chemically induced   prevention & control   MeSH
• Occupational Exposure * adverse effects   MeSH
• Primary Prevention methods   organization & administration   MeSH
• Registries * statistics & numerical data   MeSH
• Retrospective Studies MeSH
• Check Tag
• Humans MeSH
• Geographicals
• Czech Republic MeSH