sample entropy
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OBJECTIVE: High-frequency oscillations are considered among the most promising interictal biomarkers of the epileptogenic zone in patients suffering from pharmacoresistant focal epilepsy. However, there is no clear definition of pathological high-frequency oscillations, and the existing detectors vary in methodology, performance, and computational costs. This study proposes relative entropy as an easy-to-use novel interictal biomarker of the epileptic tissue. METHODS: We evaluated relative entropy and high-frequency oscillation biomarkers on intracranial electroencephalographic data from 39 patients with seizure-free postoperative outcome (Engel Ia) from three institutions. We tested their capability to localize the epileptogenic zone, defined as resected contacts located in the seizure onset zone. The performance was compared using areas under the receiver operating curves (AUROCs) and precision-recall curves. Then we tested whether a universal threshold can be used to delineate the epileptogenic zone across patients from different institutions. RESULTS: Relative entropy in the ripple band (80-250 Hz) achieved an average AUROC of .85. The normalized high-frequency oscillation rate in the ripple band showed an identical AUROC of .85. In contrast to high-frequency oscillations, relative entropy did not require any patient-level normalization and was easy and fast to calculate due to its clear and straightforward definition. One threshold could be set across different patients and institutions, because relative entropy is independent of signal amplitude and sampling frequency. SIGNIFICANCE: Although both relative entropy and high-frequency oscillations have a similar performance, relative entropy has significant advantages such as straightforward definition, computational speed, and universal interpatient threshold, making it an easy-to-use promising biomarker of the epileptogenic zone.
Most cardiac arrhythmias can be classified as atrial flutter, focal atrial tachycardia, or atrial fibrillation. They have been usually treated using drugs, but catheter ablation has proven more effective. This is an invasive method devised to destroy the heart tissue that disturbs correct heart rhythm. In order to accurately localise the focus of this disturbance, the acquisition and processing of atrial electrograms form the usual mapping technique. They can be single potentials, double potentials, or complex fractionated atrial electrogram (CFAE) potentials, and last ones are the most effective targets for ablation. The electrophysiological substrate is then localised by a suitable signal processing method. Sample Entropy is a statistic scarcely applied to electrograms but can arguably become a powerful tool to analyse these time series, supported by its results in other similar biomedical applications. However, the lack of an analysis of its dependence on the perturbations usually found in electrogram data, such as missing samples or spikes, is even more marked. This paper applied SampEn to the segmentation between non-CFAE and CFAE records and assessed its class segmentation power loss at different levels of these perturbations. The results confirmed that SampEn was able to significantly distinguish between non-CFAE and CFAE records, even under very unfavourable conditions, such as 50% of missing data or 10% of spikes.
- MeSH
- elektrofyziologické techniky kardiologické * MeSH
- entropie * MeSH
- fibrilace síní diagnóza MeSH
- katetrizační ablace MeSH
- lidé MeSH
- srdeční elektrofyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Body-focused repetitive behavior disorders (BFRBs) include Trichotillomania (TTM; Hair pulling disorder) and Excoriation (Skin Picking) Disorder (SPD). These conditions are prevalent, highly heterogeneous, under-researched, and under-treated. In order for progress to be made in optimally classifying and treating these conditions, it is necessary to identify meaningful subtypes. 279 adults (100 with TTM, 81 with SPD, 40 with both TTM and SPD, and 58 controls) were recruited for an international, multi-center between-group comparison using mixture modeling, with stringent correction for multiple comparisons. The main outcome measure was to examine distinct subtypes (aka latent classes) across all study participants using item-level data from gold-standard instruments assessing detailed clinical measures. Mixture models identified 3 subtypes of TTM (entropy 0.98) and 2 subtypes of SPD (entropy 0.99) independent of the control group. Significant differences between these classes were identified on measures of disability, automatic and focused symptoms, perfectionism, trait impulsiveness, and inattention and hyperactivity. These data indicate the existence of three separate subtypes of TTM, and two separate subtypes of SPD, which are distinct from controls. The identified clinical differences between these latent classes may be useful to tailor future treatments by focusing on particular traits. Future work should examine whether these latent subtypes relate to treatment outcomes, or particular psychobiological findings using neuroimaging techniques.
Cíle: Zabývali jsme se tradicními mírami diverzity a jejich odhady. Zkoumali jsme zpusoby, jak porovnávat citlivost ruzných mer diverzity na zmeny. Metody: Navrhli jsme nový typ odhadu pro míry diverzity. V simulacní studii jsme srovnali jeho vlastnosti, zejména vychýlení a rozptyl, se tremi zavedenými odhady. Zavedli jsme funkci, kterou jsme nazvali citlivost na zmeny míry diverzity H a studovali jsme její vlastnosti. Výsledky: Navržený odhad je v mnoha situacích srovnatelný ci lepší než zavedené typy odhadu. Citlivost na zmeny má srozumitelnou interpretaci a jednoduchý tvar. Závery: Citlivost míry diverzity na zmeny muže být využita ke srovnání chování ruzných mer diverzity a k vybrání tech mer, které jsou nejvhodnejší pro daný problém
Objectives: We dealt with the traditional measures of diversity and their sample estimates. We also studied a way to compare sensitivity to changes of different measures of diversity. Methods: We proposed a new estimator of measures of diversity. We compared our estimator with three established estimators in a simulation study. We introduced a function called sensitivity to changes of a measure of diversity H and we described its basic characteristics. Results: The proposed estimator compares favorably to other well established estimators. The sensitivity to changes has a clear interpretation and is easy to compute. Conclusions: The sensitivity of measure of diversity to changes could be used to compare behavior of different measures of diversity and to select one or few that are the most suitable for a given problem.
The binding ability of a drug to plasma proteins influences the pharmacokinetics of a drug. As a result, it is a very important issue in new drug development. In this study, affinity capillary electrophoresis, capillary electrophoresis with frontal analysis, and Hummel Dreyer methods with internal and external calibration were used to study the affinity between bovine serum albumin and salicylic acid. The binding constant was measured by all these approaches including the equilibrium dialysis, which is considered to be a reference method. The comparison of results and other considerations showed the best electrophoretic approach to be capillary electrophoresis-frontal analysis, which is characterized by the high sample throughput with the possibility of automation, very small quantities of biomacromolecules, simplicity, and a short analysis time. The mechanism of complex formation was then examined by capillary electrophoresis with frontal analysis. The binding parameters were determined and the corresponding thermodynamic parameters such as Gibbs free energy ΔG(0), enthalpy ΔH(0), and entropy changes ΔS(0) at various temperatures were calculated. The results showed that the binding of bovine serum albumin and salicylic acid was spontaneous, and that hydrogen bonding and van der Waals forces played a major role in the formation of the complex.
PURPOSE: It is well known that postural stability is influenced by visual stimuli. The influence of saccadic eye movement on postural control has been described, however, a specific response of different body segments has not been studied yet. Therefore, the aim of this study was to assess the effect of horizontal and vertical saccadic eye movements on postural stability with specific focus on upper trunk, lower trunk and lower limbs movement variability and complexity. METHODS: Eighteen elderly participants (age 70.3 ± 7.7 years) stood in bipedal stance in three visual conditions - horizontal saccades, vertical saccades and fixation. Accelerometers were attached to their lower back, sternum and shanks. Movement variability of each body segment was described by root-mean-square and sample entropy of acceleration. RESULTS: The results of the present study revealed significant influence of saccadic eye movements on anterior-posterior and vertical shanks, and vertical lower trunk movement variability described by root-mean-square. CONCLUSIONS: The correlations between results of the observed segments showed segment-specific variability patterns but generalised complexity pattern.
- MeSH
- biomechanika MeSH
- entropie MeSH
- lidé MeSH
- lidské tělo * MeSH
- neparametrická statistika MeSH
- pohyb MeSH
- postura těla fyziologie MeSH
- sakadické oční pohyby fyziologie MeSH
- senioři MeSH
- zrychlení MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Parkinson's disease (PD) is a neurodegenerative disorder which impairs motor skills, speech, and other functions such as behavior, mood, and cognitive processes. One of the most typical clinical hallmarks of PD is handwriting deterioration, usually the first manifestation of PD. The aim of this study is twofold: (a) to find a subset of handwriting features suitable for identifying subjects with PD and (b) to build a predictive model to efficiently diagnose PD. We collected handwriting samples from 37 medicated PD patients and 38 age- and sex-matched controls. The handwriting samples were collected during seven tasks such as writing a syllable, word, or sentence. Every sample was used to extract the handwriting measures. In addition to conventional kinematic and spatio-temporal handwriting measures, we also computed novel handwriting measures based on entropy, signal energy, and empirical mode decomposition of the handwriting signals. The selected features were fed to the support vector machine classifier with radial Gaussian kernel for automated diagnosis. The accuracy of the classification of PD was as high as 88.13%, with the highest values of sensitivity and specificity equal to 89.47% and 91.89%, respectively. Handwriting may be a valuable marker as a diagnostic and screening tool.
- MeSH
- algoritmy MeSH
- biologické markery MeSH
- biomechanika MeSH
- energetický metabolismus MeSH
- entropie MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- normální rozdělení MeSH
- Parkinsonova nemoc * diagnóza psychologie terapie MeSH
- senioři MeSH
- support vector machine MeSH
- systémy pro podporu klinického rozhodování * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
Previous studies reported a significant association between postural control and lower-limb strength of several muscle groups, however, they were focused especially on knee muscles and ankle plantar and dorsal flexors. The aim of the present study is to examine the correlation between the muscle strength of ankle invertors, evertors, plantar flexors, and dorsal flexors and the control of bipedal stance in young and older adults. Thirty one young (aged 22.8 ± 2.6 years) and thirty one older adults (aged 70.5 ± 7.2 years) voluntarily participated in this study. Ankle muscle strength was evaluated by an isokinetic dynamometer. Normalized peak torque and work were averaged for four repetitions and for both lower limbs. The control of bipedal stance was evaluated by the sample entropy derived from an accelerometer placed on the lumbar spine while the subject stood on a foam pad with eyes open. Results showed significant age-related differences in ankle muscle strength and sample entropy in medial-lateral direction. More interestingly, the correlation between ankle muscle strength and the sample entropy was significantly different between young and older adults. Indeed, no significant correlation was observed in the younger adults. Conversely, in the older adults, the work of the ankle evertors positively correlated with sample entropy in the medial-lateral direction during bipedal stance (r = 0.36), whereas the peak torque and work of the dorsal flexors were significantly correlated with sample entropy in the anterior-posterior direction during bipedal stance (r = 0.44 for both variables). In the young adults, results suggest that, standing on foam with eyes open is a relatively easy postural task that does not require the full ankle muscle strength capacity. Taken together, the present findings suggest that older adults have a different association between ankle muscle strength and the sample entropy during bipedal stance.
- MeSH
- kotník fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- postura těla MeSH
- posturální rovnováha MeSH
- senioři MeSH
- stárnutí * MeSH
- svalová síla * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
