JavaScript NENÍ povolen !

* Zobrazit nápovědu

MeSH: ciprofloxacin-aplikace a dávkování

9 záznamů v PubMed Filtry

Článek

Non-surgical management of thyroid abscess with ultrasound-guided fine-needle application of an antibiotic followed by sclerotization with absolute alcohol

Halenka, M
Autor Halenka, M Third Department of Internal Medicine, Division of Endocrinology, University Hospital and Faculty of Medicineand Dentistry, Palacky Universit, Olomouc, Czech Republic - milan.halenka@fnol.cz

Minerva endocrinologica. 2013 Sep ; 38 (3) : 281-7.

Minerva Endocrinol
ISSN 0391-1977
Zdroj

Thyroid abscess is a relatively rare yet dramatic condition of the thyroid gland requiring immediate therapeutic intervention. Traditionally, more or less aggressive surgical approaches and administration of broad-spectrum antibiotics have been used. Clinically less severe disease allows non-surgical treatment as well. The case report describes successful treatment of a large abscess of iatrogenic origin after biopsy of a cystic cavity. A combination of broad-spectrum antibiotics was used based on culture results, administered both orally and by repeated application directly into the abscess cavity using an ultrasound-guided fine-needle approach. Concurrent repeated evacuation of the cavity replaced drainage. Ultimately, a small residual cavity with sterile contents was managed by sclerotization with absolute alcohol. Clinical condition permitting, thyroid abscess may be successfully treated by repeated application of a targeted antibiotic, using a fine needle and ultrasound guidance, directly into the abscess cavity, with repeated evacuation replacing drainage.

Článek

Modeling the influence of non-adherence on antibiotic efficacy: application to ciprofloxacin

International journal of clinical pharmacology and therapeutics. 2007 Aug ; 45 (8) : 438-47.

Int J Clin Pharmacol Ther
ISSN 0946-1965
Zdroj

OBJECTIVE: To evaluate the consequences for antibiotic efficacy of different types of poor adherence to a short-term dosing regimen. Ciprofloxacin was taken as an example. METHOD: A simulation study on a 2-compartment pharmacokinetic model and parameter estimates taken from the literature was performed. Two empirical efficacy measures as well as a specific pharmacodynamic model of the bacterial kill curve were used. Four patterns of non-adherence were investigated: dosage omission, irregular dosing intervals, delayed dosing and treatment discontinuation. RESULTS: Errors in timing of doses with a standard deviation less than 2 h had a minor effect on antibiotic efficacy. Dosage omission, in contrast, has a significant influence on the antibacterial effect of ciprofloxacin. CONCLUSIONS: non-adherence patterns are difficult to measure experimentally, thus, recommended dosing regimens should be sufficiently robust against most of the nonintentional disturbances.

MeSH
algoritmy MeSH
antibakteriální látky aplikace a dávkování farmakokinetika terapeutické užití MeSH
bakteriální infekce farmakoterapie mikrobiologie MeSH
biologická dostupnost MeSH
ciprofloxacin aplikace a dávkování farmakokinetika terapeutické užití MeSH
lidé MeSH
odmítnutí terapie pacientem statistika a číselné údaje MeSH
plocha pod křivkou MeSH
statistické modely MeSH
stochastické procesy MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
antibakteriální látky MeSH
ciprofloxacin MeSH

Článek

Legionella detection in oropharyngeal aspirates of transplant patients prior to surgery

European journal of clinical microbiology & infectious diseases. 2006 Jan ; 25 (1) : 63-4.

Eur J Clin Microbiol Infect Dis
ISSN 0934-9723
Zdroj

MeSH
antiinfekční látky aplikace a dávkování MeSH
bakteriální proteiny genetika MeSH
ciprofloxacin aplikace a dávkování MeSH
DNA primery chemie MeSH
imunosupresivní léčba škodlivé účinky MeSH
legionářská nemoc diagnóza farmakoterapie mikrobiologie MeSH
Legionella izolace a purifikace MeSH
lidé MeSH
orofarynx mikrobiologie MeSH
peptidylprolylisomerasa genetika MeSH
polymerázová řetězová reakce metody MeSH
transplantace jater MeSH
transplantace ledvin MeSH
transplantace slinivky břišní MeSH
Check Tag
lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH
Názvy látek
antiinfekční látky MeSH
bakteriální proteiny MeSH
ciprofloxacin MeSH
DNA primery MeSH
Mip protein, Legionella pneumophila MeSH Prohlížeč
peptidylprolylisomerasa MeSH

Článek

High-performance liquid chromatographic determination of ciprofloxacin in plasma samples

Journal of pharmaceutical and biomedical analysis. 2005 Apr 29 ; 37 (5) : 851-8.

J Pharm Biomed Anal
ISSN 0731-7085
Zdroj

A new bioanalytical high-performance liquid chromatographic (HPLC) method for the determination of ciprofloxacin with norfloxacin as an internal standard was developed and validated for plasma samples. Norfloxacin is structural homologue of ciprofloxacin and exhibits similar retention properties. The quality of respective peak separation is strongly influenced by amphoteric character of ciprofloxacin and norfloxacin as well. In previously published HPLC methods on conventional C18 reversed-phase [F. Belal, A.A. Al-Majed, A.M. Al-Obaid, Talanta 50 (1999) 765-786; G. Carlucci, J. Chromatogr. A 812 (1998) 343-367], ion pair reagents were added into the mobile phase to suppress peak tailing. In comparison with endcapped and high purity silica reversed-phase sorbent (Purospher RP-18e, Merck), which yielded symmetrical peaks, separation efficiency was further enhanced in our method. Gradient elution mode using acetonitrile and phosphate buffer pH 3 on the pentafluorophenylpropyl stationary phase (250-4.6 mm Discovery HS F5, 5 microm, Supelco) was carried out. The resolution of 4.1 for ciprofloxacin-norfloxacin peaks was achieved. Sample preparation by SPE C18 (Supelclean) with recovery 72% was performed. Fluorescence detection with lambda(excit)=280 nm, lambda(emis)=446 nm was used. After the validation, the bioanalytical HPLC method was applied to pharmacokinetic studies.

MeSH
ciprofloxacin aplikace a dávkování krev farmakokinetika MeSH
lidé MeSH
vysokoúčinná kapalinová chromatografie metody MeSH
Check Tag
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
srovnávací studie MeSH
Názvy látek
ciprofloxacin MeSH

Článek

Postantibiotic effects and postantibiotic sub-MIC effects of ciprofloxacin, pefloxacin and amikacin on the biological properties of Salmonella strains

Folia microbiologica. 1997 ; 42 (4) : 327-32.

Folia Microbiol (Praha)
ISSN 0015-5632
Zdroj

The postantibiotic effect (PAE) and the postantibiotic sub-MIC effect (PASME) of ciprofloxacin, pefloxacin and amikacin were studied for Salmonella typhimurium and S. enteritidis strains. PAE was induced by 2 x and 4 x MIC of antibiotics studied for 0.5 h. After PAE and PASME their effect on prophage induction of a lysogenic S. typhimurium strain and on Congo red binding for both strains as a marker of their surface hydrophobicity was examined. The longest PAE was found after treatment with ciprofloxacin, higher values being observed with S. typhimurium. PAEs of pefloxacin and amikacin were much lower, except for the suprainhibitory concentration 4 x MIC of amikacin with S. enteritidis (6.9h). PASMEs of ciprofloxacin did not allow any regrowth of either strain. For other antibiotics the PASMEs were different while concentrations of 2 x MIC + 0.2 x MIC and 0.3 x MIC, and of 4 x MIC + 0.1 x MIC, 0.2 x MIC and 0.3 x MIC of amikacin did not allow any regrowth of S. enteritidis. PAEs of the antibiotics tested did not affect the Congo red binding by both Salmonella strains, but the PAEs of ciprofloxacin and pefloxacin expressively induced a prophage of lysogenic S. typhimurium strain. We noted the influence of Congo red binding after applying 4 x MIC + 0.1 x MIC, 0.2 x MIC and 0.3 x MIC of amikacin for S. typhimurium and 2 x MIC + 0.1 x MIC for S. enteritidis.

Článek

Influence of the postantibiotic effect and postantibiotic sub-MICs effect of netilmicin, tobramycin, ciprofloxacin and pefloxacin on alginate production by Pseudomonas aeruginosa

Folia microbiologica. 1996 ; 41 (3) : 228-32.

Folia Microbiol (Praha)
ISSN 0015-5632
Zdroj

The postantibiotic effect (PAE) (postantibiotic phase induced by 2x or 4x MIC) as well as the postantibiotic effect of subinhibitory concentrations (0.1x, 0.2x and 0.3x MIC) (PA SME) of netilmicin, tobramycin, ciprofloxacin and pefloxacin affected the production of the virulence factor alginate by a P. aeruginosa strain. Aminoglycosides and ciprofloxacin at a concentration of 4x MIC inhibited the alginate production more significantly than 2x MIC. Suprainhibitory concentrations of aminoglycosides were more effective than pefloxacin (2x or 4x MIC) and ciprofloxacin (2x MIC). PA SME demonstrated by the above antibiotics (with the exception of ciprofloxacin 2x MIC + 0.1x MIC) suppressed alginate production more efficiently.

Článek

Comparison of three dosage regimens of ciprofloxacin in urinary tract infections

International urology and nephrology. 1990 ; 22 (3) : 201-7.

Int Urol Nephrol
ISSN 0301-1623
Zdroj

Fifty-four patients with complicated UTI were administered ciprofloxacin in doses of 500 mg (30 subjects) and 250 mg (24 subjects) at 12-hour intervals. While a positive effect was noted in 96-100% upon termination of therapy, the effect was still present 3 weeks later in 90% of the high-dose, but only in 71% of the low-dose group. In 23 patients with uncomplicated UTI, a positive effect of the three-day therapy with 100 mg of ciprofloxacin at 12-hour intervals was observed in 91% of subjects. Intolerance to the agent was found in one case only. Development of resistance to ciprofloxacin was not observed.