To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

Institute of Physiology and Center for Applied Genomics Academy of Sciences of the Czech Republic 14220 Prague Czech Republic

Citace poskytuje Crossref.org

Research on Experimental Hypertension in Prague (1966-2009)

Pangenome reconstruction in rats enhances genotype-phenotype mapping and novel variant discovery

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study

Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36

Systems genetic analysis of brown adipose tissue function

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat

Translational regulation shapes the molecular landscape of complex disease phenotypes

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease

Natural variation of histone modification and its impact on gene expression in the rat genome

Recent advances in genetics of the spontaneously hypertensive rat