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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Nature genetics. 2008 Aug ; 40 (8) : 952-4. [epub] 20080629

Nat Genet
ISSN 1546-1718 | 1061-4036
Source

Language English Country United States Media print-electronic

Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid18587397

Grant support
MC_U120061454 Medical Research Council - United Kingdom
MC_U120097112 Medical Research Council - United Kingdom
Howard Hughes Medical Institute - United States

PubMed 18587397
DOI 10.1038/ng.164
PII: ng.164
Knihovny.cz E-resources

MeSH
CD36 Antigens genetics MeSH
Hypertension genetics MeSH
Rats MeSH
Kidney metabolism MeSH
Quantitative Trait Loci MeSH
Rats, Inbred SHR MeSH
Animals MeSH
Check Tag
Rats MeSH
Animals MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Research Support, N.I.H., Extramural MeSH
Names of Substances
CD36 Antigens MeSH

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

Institute of Physiology and Center for Applied Genomics Academy of Sciences of the Czech Republic 14220 Prague Czech Republic

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