Structure-function relationships in telomerase genes
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
19419346
DOI
10.1042/bc20080205
PII: BC20080205
Knihovny.cz E-resources
- MeSH
- Alternative Splicing MeSH
- Eukaryotic Cells chemistry enzymology MeSH
- Humans MeSH
- Evolution, Molecular MeSH
- Molecular Sequence Data MeSH
- Prokaryotic Cells chemistry enzymology MeSH
- Telomerase chemistry genetics metabolism MeSH
- Telomere metabolism MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Telomerase MeSH
The TERT (telomerase reverse transcriptase) subunit of telomerase is an intensively studied macromolecule due to its key importance in maintaining genome integrity and role in cellular aging and cancer. In an effort to provide an up-to-date overview of the topic, we discuss the structure of TERT genes, their alternative splicing products and their functions. Nucleotide databases contain more than 90 full-length cDNA sequences of telomerase protein subunits. Numerous in silico, in vitro and in vivo experimental techniques have revealed a great deal of structural and functional data describing particular features of the telomerase subunit in various model organisms. We explore whether particular findings are generally applicable to telomerases or species-specific. We also discuss in an evolutionary context the role of identified functional TERT subdomains.
References provided by Crossref.org
Evolution of plant telomerase RNAs: farther to the past, deeper to the roots
Origin and Fates of TERT Gene Copies in Polyploid Plants
Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes
Telomeres in Plants and Humans: Not So Different, Not So Similar
Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell
Telomere dynamics in the lower plant Physcomitrella patens
Three TERT genes in Nicotiana tabacum
