MXenes encompass attractive properties such as a large surface area, unique chemical structures, stability, elastic mechanical strength, excellent electrical conductivity, hydrophilicity, and ease of surface functionalization/modifications, which make them one of the broadly explored two-dimensional materials in the world. MXene-based micro- and nanocomposites/systems with special optical, mechanical, electronic, and excellent targeting/selectivity features have been explored for cancer nanotheranostics. These materials exhibit great diagnostic and therapeutic potential and offer opportunities for cancer photoacoustic imaging along with photodynamic and photothermal therapy. They can be applied to targeted anticancer drug delivery while being deployed for the imaging/diagnosis of tumors/cancers and malignancies. MXene-based systems functionalized with suitable biocompatible or bioactive agents have suitable cellular uptake features with transferring potential from vascular endothelial cells and specific localization, high stability, and auto-fluorescence benefits at different emission-excitation wavelengths, permitting post-transport examination and tracking. The surface engineering of MXenes can improve their biocompatibility, targeting, bioavailability, and biodegradability along with their optical, mechanical, and electrochemical features to develop multifunctional systems with cancer theranostic applications. However, challenges still persist in terms of their environmentally benign fabrication, up-scalability, functionality improvement, optimization conditions, surface functionalization, biocompatibility, biodegradability, clinical translational studies, and pharmacokinetics. This manuscript delineates the recent advancements, opportunities, and important challenges pertaining to the cancer nanotheranostic potential of MXenes and their derivatives.

Faculty of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences Isfahan 81746 73461 Iran

Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palacký University in Olomouc Šlechtitelů 27 783 71 Olomouc Czech Republic

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