Aromatase [aromatasa]
- Terms
-
aromatáza
CYP 19
CYP19
cytochrom P-450 CYP19
cytochrom P-450(AROM)
cytochrom P450 19
P450AROM
protein CYP19
-
Androstenedione Aromatase
CYP 19
CYP19
CYP19 Protein
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
- DUI
- D001141 MeSH Browser
- CUI
- M0001707
- Previous indexing
- Androstanes (1972-1974); Estrogens (1972-1974); Oxidoreductases (1972-1974)
- History note
- 86(75); was see under OXIDOREDUCTASES 1975-85
- Public note
- 86; was see under OXIDOREDUCTASES 1975-85
Combination
- antagonists & inhibitors
- Aromatase Inhibitors
Allowable subheadings
- AD
- administration & dosage 6
- AE
- adverse effects 0
- AN
- analysis 6
- BI
- biosynthesis 0
- BL
- blood 1
- CF
- cerebrospinal fluid 0
- CS
- chemical synthesis 0
- CH
- chemistry 9
- CL
- classification 0
- DF
- deficiency 5
- DE
- drug effects 3
- EC
- economics 0
- GE
- genetics 8
- HI
- history 1
- IM
- immunology 1
- IP
- isolation & purification 1
- ME
- metabolism 9
- PK
- pharmacokinetics 0
- PD
- pharmacology 9
- PH
- physiology 7
- PO
- poisoning 0
- RE
- radiation effects 0
- ST
- standards 0
- SD
- supply & distribution 0
- TU
- therapeutic use 6
- TO
- toxicity 0
- UL
- ultrastructure 0
- UR
- urine 0