Dkk-1 in human serum has a high predictive value as a potential marker (specificity 100 %, positive predictive value 100 %) in laboratory diagnosis of osteoporosis.
- MeSH
- ELISA metody přístrojové vybavení využití MeSH
- intracelulární signální peptidy a proteiny diagnostické užití izolace a purifikace krev MeSH
- klinické laboratorní techniky přístrojové vybavení využití MeSH
- lidé MeSH
- osteogeneze fyziologie genetika MeSH
- referenční standardy MeSH
- resorpce kosti genetika krev MeSH
- řízení kvality MeSH
- rozložení podle pohlaví MeSH
- statistika jako téma MeSH
- zdravotnické prostředky MeSH
- Check Tag
- lidé MeSH
Development, validation and clinical relevance of an own ELISA method for measurement of Vilip-I serum and Csf concentration is presented. First results of clinical tests suggest using this parameter in diagnosis of stroke.
Background. Increasing evidence from numerous research studies in internal medicine shows that adipocytes and adipokines are involved in primary inflammatory processes and disease. CORS-26 (collagenous repeat- containing sequence of 26 kDa protein) is a newly discovered adipokine of the C1q/TNF molecular superfamily C1q/TNF-related protein-3 (CTRP-3) secreted, inter alia in murine monocytes and adipocytes and in human adipocytes. Reported recently as a gene product of adipocyte differentiation, it shares structural similarity with the adipocyte, adiponectin. CORS-26 is much less known than other adipocytes such as leptin and resistin. Knowledge of its various functions has clinical and therapeutic implications especially in relation to obesity and the metabolic syndrome. Aims. This review aims to provide current knowledge of this adipokine. Methods. Review; sources were scientific biomedical databases Medline/PubMed, BioMedCentral, Google Scholar, Ovid, ProQuest from to 1998 to 2009. Conclusion. CORS-26 is an adipokine that regulates the secretion of other adipokines. Its effects on adipokine secretion are most probably independent of PPAR-?. As CORS-26 up-regulates adiponectin secretion, it may be involved in metabolic and immunologic pathways. The effect of recombinant CORS-26 on insulin signaling in the presence of the metabolic syndrome needs to be investigated to further evaluate the physiological and pathophysiological role of this protein.
- MeSH
- adipokiny fyziologie sekrece MeSH
- chondrogeneze fyziologie MeSH
- cytokiny sekrece MeSH
- financování organizované MeSH
- lidé MeSH
- metabolický syndrom patofyziologie MeSH
- osteosarkom patofyziologie MeSH
- tumor nekrotizující faktory fyziologie MeSH
- tunica intima patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
