Insomnia is a prevalent and disabling condition whose treatment is not always effective. This pilot study explores the feasibility and effects of closed-loop auditory stimulation (CLAS) as a potential non-invasive intervention to improve sleep, its subjective quality, and memory consolidation in patients with insomnia. A total of 27 patients with chronic insomnia underwent a crossover, sham-controlled study with 2 nights of either CLAS or sham stimulation. Polysomnography was used to record sleep parameters, while questionnaires and a word-pair memory task were administered to assess subjective sleep quality and memory consolidation. The initial analyses included 17 patients who completed the study, met the inclusion criteria, and received CLAS. From those, 10 (58%) received only a small number of stimuli. In the remaining seven (41%) patients with sufficient CLAS, we evaluated the acute and whole-night effect on sleep. CLAS led to a significant immediate increase in slow oscillation (0.5-1 Hz) amplitude and activity, and reduced delta (1-4 Hz) and sigma/sleep spindle (12-15 Hz) activity during slow-wave sleep across the whole night. All these fundamental sleep rhythms are implicated in sleep-dependent memory consolidation. Yet, CLAS did not change sleep-dependent memory consolidation or sleep macrostructure characteristics, number of arousals, or subjective perception of sleep quality. Results showed CLAS to be feasible in patients with insomnia. However, a high variance in the efficacy of our automated stimulation approach suggests that further research is needed to optimise stimulation protocols to better unlock potential CLAS benefits for sleep structure and subjective sleep quality in such clinical settings.
- MeSH
- akustická stimulace * metody MeSH
- dospělí MeSH
- elektroencefalografie MeSH
- klinické křížové studie * MeSH
- konsolidace paměti fyziologie MeSH
- kvalita spánku MeSH
- lidé středního věku MeSH
- lidé MeSH
- pilotní projekty MeSH
- polysomnografie * MeSH
- poruchy iniciace a udržování spánku * terapie patofyziologie MeSH
- průzkumy a dotazníky MeSH
- spánek pomalých vln * fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin's antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the effect of psilocybin on sleep architecture on the night after psilocybin administration. Regarding the potential antidepressant properties, we hypothesized that psilocybin, similar to other classical antidepressants, would reduce rapid eye movement (REM) sleep and prolong REM sleep latency. Moreover, we also hypothesized that psilocybin would promote slow-wave activity (SWA) expression in the first sleep cycle, a marker of sleep-related neuroplasticity. Twenty healthy volunteers (10 women, age 28-53) underwent two drug administration sessions, psilocybin or placebo, in a randomized, double-blinded design. Changes in sleep macrostructure, SWA during the first sleep cycle, whole night EEG spectral power across frequencies in non-rapid eye movement (NREM) and REM sleep, and changes in subjective sleep measures were analyzed. The results revealed prolonged REM sleep latency after psilocybin administration and a trend toward a decrease in overall REM sleep duration. No changes in NREM sleep were observed. Psilocybin did not affect EEG power spectra in NREM or REM sleep when examined across the whole night. However, psilocybin suppressed SWA in the first sleep cycle. No evidence was found for sleep-related neuroplasticity, however, a different dosage, timing, effect on homeostatic regulation of sleep, or other mechanisms related to antidepressant effects may play a role. Overall, this study suggests that potential antidepressant properties of psilocybin might be related to changes in sleep.
- Publikační typ
- časopisecké články MeSH
OBJECTIVES: The Pittsburgh Sleep Quality Index (PSQI) is one of the widely used and recommended measures of assessing sleep quality in chronic insomnia; however certain psychometric properties of the questionnaire are still unknown in this group of patients. The present study aimed to examine the internal consistency, and structural and convergent validity of the Czech version of the PSQI in chronic insomnia patients. The usefulness of the standard and alternative scoring systems was also investigated in relation to symptoms of sleepiness, insomnia, depression, and anxiety. METHODS: In our study, 105 participants filled out a series of questionnaires including PSQI, Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Beck Depression and Anxiety Inventories (BDI, BAI). RESULTS: The internal consistency of the questionnaire using Cronbach's alpha was 0.608. A series of confirmatory factor analyses revealed adequate fit for three structures. A three-factor model descriptively stood out among the rest but subsequent correlational analyses did not provide sufficient support for accepting an alternative scoring model. CONCLUSIONS: The results highlight the issue of structural variance of the PSQI and in chronic insomnia point to the important role of the PSQI components of daytime dysfunction and sleep disturbances in showing comorbid symptoms with daytime sleepiness and psychopathology.
- MeSH
- chronická nemoc MeSH
- deprese psychologie MeSH
- dospělí MeSH
- faktorová analýza statistická MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- polysomnografie MeSH
- poruchy iniciace a udržování spánku diagnóza psychologie MeSH
- průzkumy a dotazníky MeSH
- psychometrie MeSH
- reprodukovatelnost výsledků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spánek * MeSH
- stupeň závažnosti nemoci MeSH
- úzkost psychologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Cílem pilotní studie bylo uvést českou verzi testu párového asociačního učení (CZPAL) a zhodnotit, zda jsou dvě paralelní verze testu porovnatelné. Výkon v paměťovém testu jsme také porovnali mezi skupinami mladších (n = 10) a starších (n = 5) dobrovolníků. Test sestával z učení a vybavování 120 párů slov během čtyř fází: 1) učení, 2) okamžité vybavování se zpětnou vazbou, 3) vybavování s krátkým oddálením, 4) oddálené vybavování. Test se ukázal jako adekvátní pro měření deklarativní paměti a nebyl ovlivněn efekty stropu a podlahy. Výsledky dvou verzí testu byly porovnatelné a mohou být použity jako vhodné retest varianty. Mladší dospělí uspěli v testu lépe než starší, což je v souladu se zhoršením paměti v pokročilém věku. CZPAL lze využít k experimentálnímu měření deklarativní paměti v českém kontextu
The aim of the pilot study was to introduce a Czech version of the paired associative learning task (CZPAL) and to assess whether the two versions of the test were comparable. In addition, we compared the memory retention performance in two groups of younger (n = 10) and elderly (n = 5) volunteers. The task consisted of learning and recall of 120 word pairs in the following four phases: 1) learning, 2) immediate recall with feedback, 3) short-delay recall, and 4) delayed recall. The test showed to be an adequate measure of the declarative memory, which is resistant to floor and ceiling effects. The results of the two versions of the test were comparable and may thus be used as suitable retest variants. Younger adults performed better than elderly, which is consistent with the notion of age-related memory decline. Overall, the task may be used as an experimental measure of declarative memory in the Czech language context.
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuropsychologické testy * MeSH
- párové asociační učení * MeSH
- pilotní projekty MeSH
- poruchy paměti diagnóza MeSH
- prediktivní hodnota testů MeSH
- reprodukovatelnost výsledků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
