Tumour progression requires the presence of a rich vascular supply. A number of cytokines, chemokines and proteases participate in the process of tumour angiogenesis. We evaluated serum levels of angiogenin, panGRO (Growth Related Oncogene) (CXCL 1,2,3) and ENA-78 (Epithelial Neutrophil Activating) (CXCL5) in the serum of 32 patients with RCC (renal cell carcinoma) and 14 healthy blood donors by means of a protein array analysis. The patients were divided into three groups according to their disease stages (I+II, III, IV). We discovered significant differences between the blood donors and patients with RCC both in pre-operative and post-operative angiogenin, panGRO and ENA-78 levels. The increase in angiogenic factors lasted in patients even without metastases 2 months after surgery. We found no correlation between the levels of angiogenin and stages I+II, III and IV RCC. Patients with advanced carcinoma (stage III) had pre-operatively higher serum levels of ENA-78 than patients with stages I+II (p = 0,009) and IV (p< 0.001). Eight weeks after surgery the patients with stages I+II had significantly higher levels of panGRO than patients with stage IV.

• MeSH
• Chemokine CXCL1 blood   MeSH
• Chemokine CXCL5 blood   MeSH
• Adult MeSH
• Carcinoma, Renal Cell surgery   blood   pathology   MeSH
• Angiogenesis Inducing Agents blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Kidney Neoplasms surgery   blood   pathology   MeSH
• Ribonuclease, Pancreatic blood   MeSH
• Aged MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH

Předkládaný článek podává základní charakteristiky vzniku a průběhu zánětlivé reakce, která je významným adaptačním mechanizmem organizmu na působení různých škodlivin vnějšího i vnitřního prostředí. Hlavní pozornost je zaměřena na úlohu imunitního systému v průběhu zánětlivé reakce. Podrobně se zabývá přítomností a významem zánětlivé reakce v nádorovém prostředí. Podává stručnou informaci o imunitních mechanizmech protinádorové obrany. Charakterizuje podíl zánětlivé reakce na vzniku, rozvoji a progresi nádorového onemocnění.

• MeSH
• Cytotoxicity, Immunologic physiology   MeSH
• Financing, Organized MeSH
• Adaptation, Physiological physiology   MeSH
• Humans MeSH
• Inflammation Mediators physiology   classification   MeSH
• Neoplasm Metastasis immunology   physiopathology   MeSH
• Neoplastic Processes MeSH
• Immunity, Innate physiology   MeSH
• Antibodies, Neoplasm physiology   MeSH
• Inflammation physiopathology   MeSH
• Check Tag
• Humans MeSH