- MeSH
- cerebrovaskulární poruchy komplikace MeSH
- epilepsie * epidemiologie genetika patologie MeSH
- infekce centrálního nervového systému komplikace MeSH
- lidé MeSH
- náhlá neočekávaná smrt při epilepsii etiologie patologie MeSH
- poranění mozku komplikace MeSH
- rizikové faktory MeSH
- věkové faktory MeSH
- záchvaty etiologie patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.
- MeSH
- dospělí MeSH
- elektroencefalografie přístrojové vybavení MeSH
- epilepsie temporálního laloku diagnóza patofyziologie terapie MeSH
- hipokampus patofyziologie MeSH
- implantované elektrody MeSH
- kognice fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozkové vlny fyziologie MeSH
- neuropsychologické testy MeSH
- refrakterní epilepsie diagnóza patofyziologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- MeSH
- dospělí MeSH
- lidé MeSH
- Tolosův-Huntův syndrom * diagnostické zobrazování MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
OBJECTIVE: The purpose of the presented study is to determine whether there are frequency-independent high-frequency oscillation (HFO) parameters which may differ in epileptic and non-epileptic regions. METHODS: We studied 31 consecutive patients with medically intractable focal (temporal and extratemporal) epilepsies who were examined by either intracerebral or subdural electrodes. Automated detection was used to detect HFO. The characteristics (rate, amplitude, and duration) of HFO were statistically compared within three groups: the seizure onset zone (SOZ), the irritative zone (IZ), and areas outside the IZ and SOZ (nonSOZ/nonIZ). RESULTS: In all patients, fast ripples (FR) and ripples (R) were significantly more frequent and shorter in the SOZ than in the nonSOZ/nonIZ region. In the group of patients with favorable surgical outcomes, the relative amplitude of FR was higher in the SOZ than in the IZ and nonIZ/nonSOZ regions; in patients with poor outcomes, the results were reversed. The relative amplitude of R was significantly higher in the SOZ, with no difference between patients with poor and favorable surgical outcomes. CONCLUSIONS: FR are more frequent, shorter, and have higher relative amplitudes in the SOZ area than in other regions. The study suggests a worse prognosis in patients with higher amplitudes of FR outside the SOZ. SIGNIFICANCE: Various HFO parameters, especially of FR, differ in epileptic and non-epileptic regions. The amplitude and duration may be as important as the frequency band and rate of HFO in marking the seizure onset region or the epileptogenic area and may provide additional information on epileptogenicity.
- MeSH
- dospělí MeSH
- elektroencefalografie metody MeSH
- epilepsie diagnóza patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mapování mozku metody MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozek patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- MeSH
- delirium * diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- neurokognitivní poruchy diagnostické zobrazování MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- Klíčová slova
- kavernom, kavernózní angiom,
- MeSH
- epilepsie parciální * etiologie chirurgie MeSH
- kavernózní hemangiom centrálního nervového systému * diagnostické zobrazování chirurgie MeSH
- léková rezistence MeSH
- lidé MeSH
- neurozobrazování * MeSH
- senioři MeSH
- spánkový lalok MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
