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Článek

Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study

Engberink, M F
Autor Engberink, M F ] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Geleijnse, J M
Autor Geleijnse, J M ] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Bakker, S J L
Autor Bakker, S J L ] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Lifestyle Medicine Program, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Larsen, T M
Autor Larsen, T M Department of Nutrition, Exercise and Sports (NEXS), Faculty of Science, University of Copenhagen, Copenhagen, Denmark
Handjieva-Darlesnka, T
Autor Handjieva-Darlesnka, T Department of Pharmacology and Toxicology, Medical Faculty, National Transport Hospital, Sofia, Bulgaria
Kafatos, A
Autor Kafatos, A Department of Social Medicine, Preventive Medicine and Nutrition Clinic, University of Crete, Crete, Greece
Martinez, J A
Autor Martinez, J A Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
Pfeiffer, A F H
Autor Pfeiffer, A F H Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
Kunešová, M
Autor Kunešová, M Obesity Management Center, Institute of Endocrinology, Prague, Czech Republic
Jebb, S A
Autor Jebb, S A Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK

Journal of human hypertension. 2015 ; 29 (1) : 58-63. [pub] 20140424

J Hum Hypertens
ISSN 1476-5527
Medvik
Zdroj

Randomized trials have shown significant blood pressure (BP) reductions after increased protein compared with carbohydrate intake, but the effect on BP maintenance after initial weight loss is unclear. We examined the effect of a high-protein diet on the maintenance of reduced BP after weight loss in 420 overweight adults from the Diet, Obesity and Genes study. After an 8-week weight-loss period (>8% BW), subjects (42±6 years) were randomized to either a high-protein diet (23-28 en% protein) or a lower-protein control diet (10-15 en% protein) for 26 weeks. BMI after weight loss was 30.3±4.3 kg m(-2), BP was 118/73 mm Hg and 28 subjects (6.5%) used antihypertensive agents. Systolic BP during 26 weeks of weight maintenance dietary intervention increased in both treatment groups, but it was 2.2 mm Hg less (95% CI: -4.6 to 0.2 mm Hg, P=0.08) in the high-protein group than in the lower-protein control group. In 191 (pre)hypertensive subjects (baseline systolic BP⩾120 mm Hg), a larger difference was observed (-4.2 mm Hg (-7.7, -0.7), P=0.02). The effect was attenuated after adjustment for initial BP (-3.4 mm Hg (-6.9, -0.03), P=0.048), and after additional adjustment for weight change (-2.7 mm Hg (-6.1, 0.4), P=0.11). Adjustment for 24-h urinary excretion of sodium and potassium did not change the results. Diastolic BP yielded similar results. These findings suggest that a BP reduction after weight loss is better maintained when the intake of protein is increased at the expense of carbohydrates. This effect is partly mediated by body weight.