JavaScript NENÍ povolen !

Ageing is accompanied by deterioration in physical condition and a number of physiological processes and thus a higher risk of a range of diseases and disorders. In particular, we focused on the changes associated with aging, especially the role of small molecules, their role in physiological and pathophysiological processes and potential treatment options. Our previously published results and data from other authors lead to the conclusion that these unwanted changes are mainly linked to the hypothalamic-pituitary-adrenal axis can be slowed down, stopped, or in some cases even reversed by an appropriate treatment, but especially by a life-management adjustment.

MeSH
hormony metabolismus MeSH
knihovny malých molekul MeSH
lidé MeSH
receptory buněčného povrchu metabolismus MeSH
stárnutí účinky léků metabolismus patologie MeSH
systém hypofýza - nadledviny účinky léků fyziologie MeSH
systém hypotalamus-hypofýza účinky léků fyziologie MeSH
zvířata MeSH
Check Tag
lidé MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
přehledy MeSH

Článek

Computer Kinesiology: New Diagnostic and Therapeutic Tool for Lower Back Pain Treatment (Pilot Study)

BioMed research international. 2020 ; 2020 (-) : 2987696. [pub] 20200824

Biomed Res Int
ISSN 2314-6141
Medvik
Zdroj

The aim of this study was to demonstrate the effectiveness of the diagnostic and therapeutic medical information system Computer Kinesiology in physiotherapy in patients with low back pain who were not responding to conventional therapy. Computer Kinesiology is primarily intended for the diagnostics and therapy of functional disorders of the locomotor system. This pilot study population included 55 patients (Group 1) with acute and chronic back pain and 51 persons (Group 2) without back pain. The third group was a control group of 67 healthy volunteers with no evidence of musculoskeletal pathologies and no back pain. All 173 subjects were examined three times by the diagnostic part of the Computer Kinesiology method. Groups 1 and 2 were treated after every diagnostics. Group 3 was not treated. The effect was evaluated by H score. Improvements after therapy were defined by reducing the H score by at least 1 point. In Group 1, the H score decreased by at least 1 point in 87.3% (95% CI: 75.5-94.7) and in Group 2 in 78.4% (95% CI: 64.7-88.7). There was no change of distribution of H Score grade in Group 3. The improvement neither depended on gender, age, and BMI nor was it influenced by the length of the therapy. This study demonstrated a high therapeutic efficacy of the Computer Kinesiology system in patients with back pain (Group 1) and in persons without back pain (Group 2) who used the Computer Kinesiology system for primary and secondary prevention of back pain.

MeSH
diagnóza počítačová MeSH
dospělí MeSH
expertní systémy * MeSH
fyzioterapie (techniky) statistika a číselné údaje MeSH
kineziologie aplikovaná metody statistika a číselné údaje MeSH
lidé středního věku MeSH
lidé MeSH
lumbalgie diagnóza prevence a kontrola terapie MeSH
mladý dospělý MeSH
pilotní projekty MeSH
primární prevence MeSH
sekundární prevence MeSH
studie případů a kontrol MeSH
výsledek terapie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
Geografické názvy
Česká republika MeSH

Článek

Activation of Adrenal Steroidogenesis and an Improvement of Mood Balance in Postmenopausal Females after Spa Treatment Based on Physical Activity

International journal of molecular sciences. 2019 ; 20 (15) : . [pub] 20190727

Int J Mol Sci
ISSN 1422-0067
Medvik
Zdroj

Spa treatment can effectively reestablish mood balance in patients with psychiatric disorders. In light of the adrenal gland's role as a crossroad of psychosomatic medicine, this study evaluated changes in 88 circulating steroids and their relationships with a consolidation of somatic, psychosomatic and psychiatric components from a modified N-5 neurotic questionnaire in 46 postmenopausal 50+ women with anxiety-depressive complaints. The patients underwent a standardized one-month intervention therapy with physical activity and an optimized daily regimen in a spa in the Czech Republic. All participants were on medication with selective serotonin reuptake inhibitors. An increase of adrenal steroidogenesis after intervention indicated a reinstatement of the hypothalamic-pituitary-adrenal axis. The increases of many of these steroids were likely beneficial to patients, including immunoprotective adrenal androgens and their metabolites, neuroactive steroids that stimulate mental activity but protect from excitotoxicity, steroids that suppress pain perception and fear, steroids that consolidate insulin secretion, and steroids that improve xenobiotic clearance. The positive associations between the initial values of neurotic symptoms and their declines after the intervention, as well as between initial adrenal activity and the decline of neurotic symptoms, indicate that neurotic impairment may be alleviated by such therapy provided that the initial adrenal activity is not seriously disrupted.

Článek

Steroidní metabolom jako indikátor efektu lázeňské léčebně rehabilitační péče
[Steroidal metabolomic biomarkers as an indicator of the effect of spa therapy and balneotherapy]

Rehabilitace a fyzikální lékařství. 2018 ; 25 (3) : 99-108.

ISSN 1211-2658
Medvik
Zdroj

Za účelem objektivizace změn hladin metabolomu neurosteroidů u dospělých klientů po komplexní lázeňské léčebně rehabilitační péči navázaly v roce 2017 vzájemnou spolupráci Endokrinologický ústav v Praze a Priessnitzovy léčebné lázně a.s. v Jeseníku. Autoři prezentují soubor 70 probandů, kteří absolvovali při nástupu a dimisi baterii klinických a laboratorních vyšetření. První výsledky změn metabolomu neurosteroidů, kineziologického vyšetření diagnostickou části Computer Kinesiology a výsledky Knoblochova dotazníku sebeposuzovací škály N-5 ukazují jednoznačně efekt léčení v lázních.

The Endocrinological Institute in Prague established the cooperation with in Priessnitz's spa a.s. in Jesenik intention to objectify changes in neurosteroid metabolomic biomarkers levels in adult clients after spa treatment, in 2017. The authors present a set of 70 probands. The first results of changes in the levels of neurosteroids, serotonin and homocysteine metabolite clearly demonstrate the effect of treatment in the spa. The kinesiological examination of the diagnostic part of Computer Kinesiology and the numeric outputs of Knobloch questionnaire (N-5 self- -judging scale) correlate with endocrinological results.